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MedicationRapamycin
Also: sirolimus
Last scientific update: jun 2026
Rapamycin (sirolimus) is a drug that inhibits the protein mTOR, a central switch for growth and aging. In animals it extends lifespan, making it one of the most discussed longevity agents.
Rapamycin at a glance
In animalsExtends lifespanModerate
In humansNot yet provenPreliminary
MechanismInhibits mTOR
UseOff-label, only under supervision
Rapamycin is promising in animals, but in healthy humans it is unproven and not without risk, so experimental.
24 studies4 answersupdated jun 2026
Evidence per claim
Not yet proven for healthy longevity in humans
View evidence →Works via mTOR, a key route in aging
View evidence →Stimulates autophagy
View evidence →As uncertain as other candidates such as spermidine
View evidence →Practical use
For whom
Mainly of interest for research and people following it experimentally through a doctor.
Not for whom
Not meant for self-experiment; there are real side effects and risks.
Usual dose
No proven anti-aging dose in humans; only under medical supervision.
Key caveats
Suppresses the immune system at higher doses; long-term safety in healthy people is unknown.
What we know, and don't
Known
Extends lifespan in several animal species
Inhibits mTOR, a central aging route
Is being seriously studied in humans
Not yet
Whether it extends life in healthy people
The safe dose and frequency
The long-term effects
Common misconceptions
"Rapamycin is a proven anti-aging pill."
Not shown. In humans that is not yet shown.Strong evidence
"It is harmless to try yourself."
False. There are real side effects; only under supervision.Strong evidence
How Rapamycin connects
Related
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