longevitywatch

Can people soon grow new teeth?

Stem cell research has produced tangible results for repairing damaged tooth tissue, such as in children treated with stem cells from baby teeth. Growing a completely new tooth in people has not yet been achieved.

Enamel cannot repair itself, and a lost tooth does not normally grow back. Yet researchers have managed to produce enamel-forming cells from stem cells in the laboratory. That is a remarkable step, but it is not yet a treatment: everything happens in the lab, not in a patient's mouth.

There are also promising results in animal studies using stem cells taken from dental pulp, the soft layer on the inside of a tooth, and from the periodontal ligament, the tissue that anchors a tooth in the jaw. Scientists are also gaining a much better understanding of the processes that cause a tooth to form before birth, and are trying to use that knowledge to develop biologically grown replacement teeth. A complete, fully functioning replacement tooth has not yet been achieved in people.

There is one positive result in real patients, but it involves a very specific situation. Children with a damaged permanent tooth received stem cells implanted from their own baby teeth. After twelve months, the dental pulp, including blood vessels and nerves, had measurably grown back, and the root had continued to develop. After two years there were no side effects, but the study included only twenty patients. Moreover, this concerns the repair of a damaged tooth in children with roots that had not yet fully formed, not the growth of a completely new tooth.

Biomaterials used as a scaffold for tooth tissue play a supporting role in this research. Researchers consider root regeneration a somewhat more achievable short-term goal than regenerating an entire tooth, but here too, real-world use is not yet in sight. For anyone who loses a tooth today, an implant remains the best option, or, if the natural tooth can just about be saved, targeted dental treatment.

The evidence
7 studies · 1 randomised trial · ≈ 46 participants

This answer draws on a study of 26 children on stem cell implantation in damaged teeth, several overview articles on stem cell technology and tissue engineering for tooth regeneration, and one overview article on intentional tooth replantation. The only human study with a positive result is small and limited to a specific situation. For complete tooth regeneration, only laboratory and animal research exists. None of the overview articles combined results statistically; they describe the current state of the field.

Last checked: October 2026 · how this was judged
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