longevitywatch

Do gut problems play a role in poor bone formation?

A disrupted gut microbiome is associated with lower bone density, and the biological mechanisms are fairly well described. Probiotics sound appealing, but have not yet been sufficiently proven in humans. For now, focus on a varied, fibre-rich diet and limit salt, as that has the best evidence base for both your gut and your bones.

Yes, the gut demonstrably influences bone health. Your gut microbiome, the collection of bacteria living in your intestines, affects bone remodelling through several pathways at once. Beneficial gut bacteria produce short-chain fatty acids that inhibit bone-breaking cells (osteoclasts) and stimulate bone-building cells (osteoblasts). They also improve calcium absorption and keep certain immune cells in check that would otherwise drive bone breakdown.

When the balance of bacteria in your gut is disrupted, researchers call this dysbiosis. Both in animal studies and in clinical research we see that dysbiosis is associated with lower bone mineral density and a higher risk of osteoporosis. In humans the association is clearly present, but it has not yet been fully established that the imbalance in the gut is the direct cause of bone loss. The two most likely influence each other in both directions.

Whether this can be reversed with probiotics or prebiotics is the question occupying many researchers. In animal studies, bone density visibly improves after such interventions. In humans there are promising signals, but the studies are still small and the results sometimes contradict each other. It is too early to recommend probiotics as a proven remedy for poor bone formation.

Two other factors that influence bones through the gut: eating a lot of salt is associated with lower bone mineral density, partly because sodium unfavourably alters the composition of gut bacteria. And there are early indications that regularly skipping breakfast may reduce bone density, possibly through calcium metabolism and the microbiome. That evidence is weak and not free of confounding factors, however, so no firm conclusions can yet be drawn from it.

The evidence
8 studies · 2 systematic reviews

Claims based on multiple reviews and clinical studies (PMID 28965190, 39643654, 37834025, 35283172, 39387683, 40557919, 40086509, 40845418). The mechanistic evidence (via immune cells and short-chain fatty acids) is reasonably well supported, primarily in animal models. Clinical data in humans are consistent in direction but still limited in size and uniformity.

Last checked: September 2026 · how this was judged
Related answers

Does drinking a lot of alcohol weaken your bones?

Chronic heavy drinking demonstrably weakens your bones and substantially raises the risk of a hip fracture; for your bones there is no safe level above two drinks per day.

Do you really need calcium supplements for strong bones?

Whether you need calcium supplements depends strongly on your age and circumstances: for young, healthy women there is no evidence of benefit, while people over 50 may benefit from calcium plus vitamin D, provided the increased risk of kidney stones is taken into account.

Moderate evidence

Can eating disorders such as anorexia cause permanent bone damage?

Anorexia causes permanent bone damage in the majority of cases, particularly when the condition begins during adolescence. Discuss a bone assessment with your doctor if you or someone you know is affected by this.

Does being overweight affect your bone density?

Being overweight does not straightforwardly increase bone density, and the location and amount of fat strongly determine whether the skeleton benefits or is harmed. If you are considering losing weight, do so gradually and combine it with strength training to limit bone loss.

Does boron as a supplement do anything for your bones?

Boron appears useful if you are not getting enough of it, but there is no good evidence that extra supplementation makes your bones stronger if you are already getting sufficient amounts. Make sure you are getting enough calcium and vitamin D first, and discuss boron supplementation with your doctor if you are dealing with osteoporosis.

Preliminary evidence

Do carbonated drinks damage your bones?

Regularly drinking large amounts of sugary carbonated drinks is associated with lower bone density, especially in women and during puberty. Moderate consumption appears less harmful, but it is preferable to replace soft drinks with beverages that support bone development.

Yes · Moderate evidence
Related research
29 Sep
Transplanted immune cells donate mitochondria to brain cells
25 Sep
New atlas maps aging in individual kidney cells
21 Sep
A brain protein reverses aging signs in mice
Don't see your question?
Ask it and we'll look it up for you.
Ask a question →
Newsletter

Stay in the loop

Twice a week, the most important longevity research in your inbox.