longevitywatch

How harmful are trans fats, exactly?

Industrial trans fats are demonstrably harmful to your heart and blood vessels, even in small amounts. Avoid them by checking ingredient lists for 'partially hydrogenated oil'.

Industrial trans fats raise LDL cholesterol (the 'bad' cholesterol) and lower HDL cholesterol (the 'good' cholesterol). That combination is particularly unfavourable, and both dietary studies and studies in people confirm this effect.

The heart risk is concrete: for every 2% of your daily calories that comes from industrial trans fats, the risk of a heart attack or death from heart disease rises by 24 to 32%, compared with other fat sources. That is a large effect for a relatively small amount, and many studies following people for years arrived at this estimate.

Beyond cholesterol, trans fats also damage the inner lining of blood vessels, an early sign of hardening of the arteries. They also raise substances in the body that drive inflammation, such as CRP and interleukin-6. Both effects have been found in dietary studies as well as in people followed over time, although the certainty is somewhat lower than for the heart risk.

There are also hints of poorer insulin sensitivity and greater accumulation of belly fat, but those links are still weak and not sufficiently confirmed to make firm statements about. Possible effects on fertility or brain health are mentioned in overview articles but have barely been studied.

Trans fats that occur naturally in dairy and beef or lamb do not appear to carry a measurable increased heart risk at the amounts people normally eat. Gram for gram, they affect cholesterol just as unfavourably as the industrial variety, but intake is usually much smaller. The ban or strict limits that have now been introduced in several countries and by the WHO apply exclusively to industrial trans fats, with the estimate that tens of thousands of heart disease events per year could be prevented if they were removed from the food supply worldwide.

The evidence
7 studies

All sources are reviews; no primary studies or combined analyses were supplied as individual references. The strong statements about heart risk are based on studies following large groups of people over time and a combined analysis of multiple studies, as described within those reviews.

Last checked: August 2026 · how this was judged
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