longevitywatch

Does zinc help with acne and healthier skin?

Yes · Moderate evidence

Zinc demonstrably reduces inflamed spots, but works less well than the usual treatments such as benzoyl peroxide. It is most useful if you cannot tolerate standard treatments or as a complement to them.

People with acne have, on average, lower zinc levels in the blood than people without acne. Whether that is a cause or a consequence is not certain, but it does provide a biological rationale for looking at zinc as a treatment.

Zinc works for acne. Both pills and ointments or creams containing zinc reduce the number of inflamed spots, as shown consistently across multiple studies, including a meta-analysis. The nuance matters, though: zinc performs less well than standard treatments such as benzoyl peroxide or antibiotics. For mild acne, or as a supplement to other treatment, it is nevertheless a realistic option.

With oral zinc supplements, some users experience gastrointestinal complaints, particularly nausea. That is the most frequently reported side effect. Applying zinc to the skin does not cause such complaints. For people who are pregnant and want to treat acne, oral zinc is cited in the medical literature as one of the relatively safe options, although that evidence is limited.

How well zinc performs compared with other treatments is difficult to establish firmly. The comparative studies that do exist are of moderate to low quality. Many studies are also small and methodologically limited. Larger, better-designed studies are still lacking.

Beyond acne, there is limited evidence that zinc also helps with hair loss, certain inflammatory skin conditions, and some skin infections. For those applications the evidence is thinner and larger studies are needed. An experimental formulation in which zinc oxide is coated with hyaluronic acid showed positive results in a small trial, but that product is far from available as a standard treatment.

The evidence
8 studies · 2 meta-analyses

Based on multiple meta-analyses and reviews (PMID 32860489, 29193602, 37878272, 32356369), a Cochrane review (PMID 32356369), an overview article on dermatological zinc use (PMID 35437093), a guideline for acne in pregnancy (PMID 38453786), and a small clinical trial with an experimental zinc formulation (PMID 40254135). The comparative evidence relative to standard treatments is of low to very low quality.

Last checked: August 2026 · how this was judged
Related answers

Does skin cycling really work better for your skin?

Skin cycling as a method has never been clinically tested, so it cannot be said to work better than a regular routine. If you want to do something for your skin, a moisturising cream with ceramides or urea is better supported by evidence than the schedule built around it.

Insufficient evidence

What actually works against skin aging?

Using sunscreen daily is the best-supported way to slow skin ageing, supplemented by not smoking, moderate alcohol consumption and sufficient sleep. Cosmetic options such as thread lifts and honey in creams have a weaker or not yet sufficiently proven basis and call for a critical weighing of the risks.

Moderate evidence

Does astaxanthin help protect your skin from the sun?

Astaxanthin (3-6 mg/day) appears to give the skin some additional UV resistance, but should never replace your sunscreen: the protection is limited and the evidence is largely based on small studies.

Yes · Moderate evidence

Does sunscreen also protect against skin ageing?

Using broad-spectrum sunscreen daily demonstrably slows sun-induced skin ageing; anyone with concerns about chemical filters can switch to a mineral variant containing zinc oxide or titanium dioxide without any loss of protection.

Yes · Moderate evidence

Is zinc beneficial for my immune system?

Zinc is beneficial for your immune system if you have a deficiency or belong to a risk group such as older adults or severely malnourished individuals; for the common cold, a dose of up to 30 mg per day may shorten symptoms, but high doses without an indication are more likely to be harmful than helpful.

Yes · Moderate evidence

Is too much zinc harmful?

Too much zinc is certainly harmful: as an adult, stay below 25 mg per day (the EFSA limit) and be cautious with high-dose zinc supplements, because even moderate over-supplementation can disrupt copper balance.

Yes · Moderate evidence
All Zinc answers on “What works” →
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