Most mutated cells never become tumors. The ones that do have a trick: they remodel the tissue around them to create a safe haven for growth.
People with certain cancer-linked gene mutations sometimes respond better to immunotherapy. New research explains why: faults in two well-known genes dramatically alter the environment surrounding a tumour.
Organised clusters of immune cells inside tumours follow the same structural pattern across dozens of cancer types. That is the headline finding of a large-scale spatial atlas of tumour immunity.
A protein best known for helping other proteins fold correctly turns out to play an unexpected role in the cellular response to DNA damage.
CRISPR normally works on DNA. A new system targets RNA instead, and can kill specific cells on demand.
Most cancer immunotherapies work only for a minority of patients. A new mRNA treatment drastically increased immune responses in mice. It also boosted responses to flu and COVID-19.
Metformin has been the most prescribed type 2 diabetes drug for decades. New research now shows it also inhibits cancer cells through a specific component of the cell’s energy-producing machinery.
Tumors damage surrounding tissue. That has long been known. But a new study shows they also actively block the renewal of nearby healthy stem cells by mimicking a signal that normally only…
Obesity raises the risk of Alzheimer’s disease. The link has been suspected for years, but the underlying biology was murky. A new review maps the shared mechanisms in detail.
Scientists have engineered nanoparticles capable of activating an immune response across the entire body simultaneously — not just at the site of injection.
When a key energy-producing protein is reduced in cancer cells, the tumors don’t slow down — they accelerate. New research reveals a metabolic paradox at the heart of cancer biology.
Lung fibrosis replaces healthy tissue with scar tissue, makes breathing progressively harder, and has almost no treatments that reverse the damage.
Every cell in the body follows a tightly regulated cycle of growth and division. When that regulation breaks down, cancer follows.
Early cancer detection through a blood test — the so-called liquid biopsy — is one of the most promising developments in preventive medicine.
Fusobacterium nucleatum is a bacterium that normally lives in your mouth but is also found deep inside tumors. Scientists have long known it can fuel cancer.
Cancer cells have a way of making themselves invisible to the immune system’s hunters.
Cancer cells that reach the heart barely grow at all. Researchers have now discovered that the mechanical force of a beating heart actively suppresses tumor cells — an effect that holds up…
Blood cancer cells cloak themselves in a layer of sugar molecules that tells the immune system to stand down.
Cancer cells are skilled escape artists. But leukemia cells have a particularly elegant trick: they coat themselves in sugar molecules that actively send a stop signal to the immune system.
Researchers have found that two genes that normally put a brake on cell growth are lost in many cancers — and that their loss unleashes one of the most well-known growth molecules…
CAR T-cell therapy transformed blood cancer treatment. But for solid tumors — the most common cancers — it has largely failed.
Older people are more likely to see their cancer spread to other organs. Researchers now have a molecular explanation: aging liver cells leak tiny packages of genetic material that make tumors elsewhere…
Cancer cells burn sugar differently from healthy ones, leaving a distinct chemical trail.
Mitochondria have long been known as the cell’s energy generators. But new research published in Science reveals they also control how effectively your immune system attacks tumors — and that changes everything…
Half of our DNA consists of genetic elements that can copy and paste themselves into new locations.
A study of 527 women has mapped how breast tissue changes with age in unprecedented spatial detail: cell density drops, proliferation slows, and inflammatory immune cells take up proportionally more space.
CAR T-cell therapy is one of the most powerful tools oncology has produced in decades — but its complexity and cost put it out of reach for most patients.
CAR T-cell therapy is one of the most powerful tools oncology has produced in decades — but its complexity and cost put it out of reach for most patients.