Alzheimer’s brains are in a constant state of inflammation. But why doesn’t that inflammation switch off on its own?
In Alzheimer’s disease, the brain’s immune system stays permanently switched on. Researchers at Scripps Research have now identified the protein responsible and, for the first time, explained exactly why it gets stuck…
When it comes to diseases like Alzheimer’s and Parkinson’s, attention typically focuses on neurons dying.
The brain has its own immune cells that are supposed to clean up toxic debris, including the protein clumps linked to Alzheimer’s disease. With age, they become less effective.
The tau protein, best known for its role in Alzheimer’s disease, appears to be involved in how neurons respond to DNA damage during cell cycle activation.
CBD is best known for easing pain or anxiety. But new research in mice suggests it may also suppress inflammation in the brain.
Not everyone’s brain ages at the same pace. A single gene variant appears to make neurons more resistant to harm.
Tau protein is best known as a culprit in Alzheimer’s disease. But it turns out to play an entirely different role too: encoding long-term memories.
An enzyme that received little scientific attention turns out to play a major role in amyloid accumulation in the brain.
The number of clinical trials testing Alzheimer’s drugs is rising steadily. Yet approved treatments remain few. Researchers reviewed 192 ongoing trials to map where the field stands.
A single brain scan and an algorithm. That combination may be enough to predict whether someone will develop Alzheimer’s, how fast their cognition will decline, and how severe the diagnosis will be…
Old mice with Alzheimer’s features behaved like healthy young animals after a nanoparticle treatment. The therapy addresses two of the brain’s core problems at the same time.
Most people with dementia do not have one disease. They have two or three simultaneously. That makes treatment research far more complicated than assumed for decades.
One gene shapes Alzheimer’s risk more than any other. But the two most studied variants — one harmful, one protective — have remained poorly understood at the molecular level.
The brains of Alzheimer’s patients contain cells with DNA errors not found in healthy brains.
Obesity raises the risk of Alzheimer’s disease. The link has been suspected for years, but the underlying biology was murky. A new review maps the shared mechanisms in detail.
By the time someone forgets a name or gets lost on a familiar route, Alzheimer’s disease may have been quietly progressing in their brain for twenty or thirty years.
Why does one person develop severe Alzheimer’s while another with equally damaged brain tissue stays sharp into their eighties?
The most advanced Alzheimer’s treatments ever developed can now demonstrably remove the protein clumps long blamed for the disease. Patients, however, are barely improving.
After decades of research focused on amyloid plaques and tau tangles, a study points to a neglected signalling molecule in the brain — and drugs that target it already exist.
Tau protein is present in almost every brain over the age of eighty, yet most people never develop dementia.
The same technique that has transformed cancer treatment — reprogramming immune cells to hunt down disease — is now being aimed at Alzheimer’s.
APOE4 is the most powerful known genetic risk factor for Alzheimer’s disease. But what does it actually do in the brain, long before the first symptoms appear?
Instead of targeting amyloid or tau — the usual suspects in Alzheimer’s research — scientists focused on a neuropeptide that had been sitting in the background for decades.
Before a single memory slips, something has already gone wrong deep in the brain. Mice carrying the most dangerous genetic variant for Alzheimer’s have smaller, chronically overexcited neurons — and researchers have…
Millions of people carry the APOE4 gene, the strongest known genetic risk factor for Alzheimer’s.
A blood test that can detect Alzheimer’s disease years before symptoms appear sounds like unambiguous progress.
We’ve known for years that gum disease is bad for your heart. Now the evidence is growing that the same bacteria colonising your gums may also be reaching your brain — and…