A gene that barely registers outside research labs turns out to significantly extend the lifespan of fruit flies. And it does so by improving how mitochondria work.
Exercise damages your cells. But that damage is precisely what makes you healthier. A protein called HMGB1 appears to be the key to that paradox.
A little-known protein has been shown to extend the lifespan of fruit flies by improving how their cells produce energy.
What if you could test how a cell responds to a genetic intervention before running a single experiment?
Scientists keep producing new tools to measure biological aging. The latest uses amino acid levels in blood. But does it actually tell us anything new?
There is a molecular brake on your DNA repair system. The more active that brake, the faster cells accumulate errors — and the faster you age.
One changed letter in a protein’s code can alter everything. New large-scale research maps how amino acid substitutions affect the amount of protein present in a cell.
Science moves on the right questions. A gathering of leading aging researchers tried to define those questions from scratch. What emerged says a great deal about where the field stands today.
Some people reach a hundred in reasonable health. Others decline sharply in their seventies. A new review asks why, and the answer is more complicated than most longevity research suggests.
Mitochondria, the energy-producing structures inside cells, decline with age. New research identifies a specific lipid molecule as a likely culprit: phosphatidylcholine, the most abundant fat in mitochondrial membranes, drops significantly as organisms…
Cells have ways to permanently silence certain genes. One of those guardians is the protein MORC2.
What if aging is not a biological puzzle but a physics problem? A growing group of researchers is applying the laws of physics to the aging process.
Genetically identical cells in identical environments still make different choices about what they become.
Tendons heal poorly. They have limited blood supply, repair slowly, and in older adults that repair is even slower.
Why do humans, mice, and whales show the same epigenetic aging patterns, despite living completely different lives? A new model offers a surprisingly simple answer.
Aged skin heals more slowly. That has long been known. But a new experiment shows that removing damaged cells can significantly speed up that process.
Cells under stress temporarily halt protein production. That sounds like a useful defence. But researchers found that chronic activation of this system actually accelerates aging.
A small chemical tag on an amino acid turns out to play a surprisingly large role in cell biology.
Exercise improves metabolism in dozens of ways, but pinpointing which molecule causes which benefit is genuinely hard.
European health data sits locked in national systems. A new proposal in Science argues for a different approach: instead of sharing patient data, share the AI models trained on it.
Metformin has been the most prescribed type 2 diabetes drug for decades. New research now shows it also inhibits cancer cells through a specific component of the cell’s energy-producing machinery.
Blue zones are held up as proof that certain environments make people live longer. But how solid is the data behind that idea?
Muscle stem cells in older animals struggle to activate. A new study pinpoints the reason: a specific metabolic pathway fueled by glutamine quietly shuts down with age.
Tumors damage surrounding tissue. That has long been known. But a new study shows they also actively block the renewal of nearby healthy stem cells by mimicking a signal that normally only…
Measuring tissue aging usually requires a biopsy or imaging scan. A newly developed probe could make it as simple as collecting urine after a single injection.
People in excellent physical condition score almost identically to sedentary peers on most mainstream epigenetic aging clocks. That reveals a fundamental limitation in how these tools are built.
Mammals that live in organized social groups tend to live longer than solitary species. The pattern holds across dozens of species and is stronger than many other known longevity factors.
Detecting the buildup of aging cells in the body has always required invasive tissue samples. A new study suggests a simple urine test could do the job instead.
Lung disease kills more people than most realize. And aging is the silent driving force behind nearly all of it — even when the immediate cause appears to come from outside.
Aging tissue is stiffer than young tissue. It turns out that stiffness is not just a symptom of aging — it may be one of the reasons repair fails in the first…
Older people often say time seems to pass faster than it used to. A new theory links this to a concrete mechanism: the energy deficit in aging cells.
Astronauts returning from space look as though they have aged by years. That is not coincidence.
A researcher at Rockefeller University has mapped how aging unfolds across nearly seven million cells from 21 mouse tissues at three different ages.
Inject genetic code into cells, then switch it on from outside the body using an electromagnetic device. It sounds like science fiction.
Age-related muscle loss has long been blamed on stem cells that simply wear out over time.
Your body is full of proteins that have been chemically modified by sugar — not because of what you eat, but because of basic metabolism.
A shark older than five hundred years, swimming through waters it has known since before the Industrial Revolution.
Imagine a trial on a dietary intervention finding that participants become biologically younger.
A three-year-old mouse is near the end of its life. A thirty-year-old naked mole-rat looks barely different from how it did at five.
Every cell in your body lives inside a kind of scaffolding — a web of proteins that provides structure, relays signals, and helps determine whether a cell stays healthy or drifts into…
April 2026 was a busy month for researchers treating aging as a biological problem to be solved.
When a key energy-producing protein is reduced in cancer cells, the tumors don’t slow down — they accelerate. New research reveals a metabolic paradox at the heart of cancer biology.
Most aging researchers focus on fixing the body’s damage. But a growing faction argues that some things are simply too broken to repair — and wants to replace them instead.
Spatial transcriptomics — the technology that maps which genes are active where inside a tissue — is one of the most exciting tools in aging research.
One of the twentieth century’s most devastating epidemics may have done something extraordinary: triggered a measurable evolutionary shift in human populations within just a few decades.
Millions of people are already experimenting with senolytic treatments to slow aging. A new study now shows that one of the most popular combinations causes brain damage strikingly similar to multiple sclerosis…
April 2026 was a busy month for longevity science. New findings, clinical progress and policy shifts — a look at where the field stands. Lifespan.
Kangaroos independently evolved thick tooth enamel, just like several other large mammals did before them.
The field of anti-aging research moves fast. April 2026 brought a wave of new results, company announcements, and scientific insights.
Life on Earth uses twenty amino acids to build every protein in every living thing. Researchers wondered whether all twenty are truly necessary — and used artificial intelligence to find out.
Naked mole rats live thirty years. Ordinary mice barely manage two. The answer to that gap may not lie in the big picture of biology, but in the smallest working parts of…
COPD — the lung disease that slowly robs people of their breath — has long been considered irreversible.
What if the key to fighting aging isn’t repairing damaged cells and organs, but simply replacing them?
A worm barely a millimeter long can sniff out bacteria enriched with a specific amino acid it cannot make itself.
The textbook account of how adult blood is made has a clean simplicity to it: bone marrow stem cells do the job, period.
Mitochondria — the structures inside every cell that generate energy — are known to decline with age. What is less understood is why.
Heart muscle cannot grow back after a heart attack. The dead tissue becomes scar tissue, and that scar gradually undermines the heart’s ability to pump.
Dasatinib and quercetin — the most widely used senolytic combination in longevity circles — causes damage to specific brain regions in mice that closely resembles what is seen in multiple sclerosis.
Conferences are filling up, startups are raising money, and the first human trials of treatments aimed at reversing biological aging are underway.
Researchers have identified a molecular switch inside the body’s blood-forming cells that gets triggered by stress and appears to accelerate the aging of the immune system.
In a mouse model of spinal disc degeneration, a cheap, decades-old drug combination beat a newer and more expensive competitor.
Not all ant colonies build at the same pace. New experiments show that the age structure of a colony — how many young versus old workers it contains — directly determines how…
On June 4, 2026, a full-day longevity event in Lisbon will bring together scientists, clinicians, investors, and founders. The organizers promise a program stretching from ancestral nutrition wisdom to cutting-edge biotech.
Your DNA doesn’t change, but the way your genes are read does. A new review in Science maps how epigenetic changes — driven by diet, stress, and environment — shape long-term health…
Cells that have stopped dividing and are normally considered a hallmark of aging turn out to play a crucial role in wound healing.
A roundup from the Lifespan Research Institute surveys what happened in rejuvenation science over the first months of 2026.
Aging research in Europe is well-funded and growing fast. But scientists in different countries are largely working in isolation, duplicating efforts and missing insights that only emerge from sharing data at scale…
When a heart attack kills part of the heart muscle, the human body has no way to replace it.
Every cell in your body carries nearly identical DNA, yet a liver cell and a brain cell look and behave completely differently.
In longevity science, the word ‘breakthrough’ gets used a lot. A recent roundup from Lifespan.io surveys the state of the field.
When the blood-making system comes under pressure, the body has a fallback plan. Researchers have discovered an entirely unknown pathway that allows red blood cells to acquire the building blocks for hemoglobin…
Scientists have reprogrammed blood stem cells to generate a continuous supply of protective proteins — potentially for the entire lifespan of a patient.
Two of the most discussed phenomena in aging research — chronic low-grade inflammation and the biological clock of cells — are more tightly linked than previously understood.
Two of the most discussed processes in aging science — chronic low-grade inflammation and epigenetic changes in DNA — turn out to be closely connected.
Ribosomes are the molecular machines inside every cell that build proteins. They were long thought to work identically in everyone.
Scientists studying how genes drive aging have long faced a frustrating problem: the tools to switch genes on and off in living animals work, but not cleanly enough.
What if your immune system could be programmed once and then protect you for life — without ever needing a booster?
It sounds counterintuitive: slightly damaging your cells to make them stronger. Yet that’s precisely the principle behind one of the most intriguing ideas in aging research.
A drug used for decades to treat a rare blood cancer turns out to also clear senescent cells — the so-called zombie cells associated with aging and age-related disease.
Bacterial cells can radically shift their internal molecular composition in response to changing conditions. Yet something remains surprisingly constant.
After damage, lung stem cells produce their own molecular signal that tells them when to start regenerating.
Suppressing IGF-1, a growth signaling pathway that has been studied for decades as a key to longer life, barely extends lifespan in mice with heavily damaged mitochondria.
Ten thousand years ago, humans started growing crops and raising animals. That shift didn’t just change dinner — it accelerated our biological evolution in ways scientists are only now beginning to fully…
Every cell in your body is constantly building proteins — the molecules that do nearly everything. But exactly how that production is controlled has remained surprisingly murky.
A salamander loses a leg and grows it back. We lose a fingertip and it’s gone forever.
A one-time treatment that makes your body produce its own medicines — for life. Researchers have now shown this is possible, by reprogramming blood stem cells to churn out powerful protective proteins…
When mice are trained to fear a specific odor, the structure of their offspring’s smell system changes — even though those offspring never encountered the scent themselves.
Nearly half of the human genome consists of remnants from ancient viral infections. In youth, cells keep these sequences locked down. As we age, the locks weaken.
NAD+ supplements have attracted enormous attention as potential anti-aging interventions.
A fragment of a protein that normally helps organise the cell’s genetic material can create small, temporary gaps in DNA — and those gaps, counterintuitively, appear to trigger repair processes that roll…
Cells are wrapped in a thin membrane made mostly of fat. For decades, that membrane was treated as a passive scaffold.
A molecule central to how cells make energy drops sharply as we age. Scientists have known for years that supplements can partially restore it.
Some animals simply grow a new leg when the old one is gone. Humans don’t. Scientists have known for decades that a fundamental difference must exist between species that can regenerate and…
Every cell contains millions of proteins that must be in exactly the right place at the right time.
Life Biosciences is about to become the first company to test a therapy that makes cells biologically younger — not as a treatment for a specific disease, but for aging itself.
Salamanders can regrow entire limbs. Humans can’t — with one exception: the tip of a finger.
Topping up a single supplement helps a little. But what if you also stopped the leaking?
The FDA doesn’t officially recognise aging as a disease. Yet this year, for the first time, a therapy designed to make cells biologically younger is entering human trials.
To eventually grow replacement organs — or even whole bodies — scientists first need to understand how an embryo does it.
Mitochondria have their own DNA, and errors in it accumulate as we age.
Pulmonary fibrosis is one of the most devastating age-related diseases — the lungs stiffen progressively, with no effective cure.
Fat tissue ages faster than most other parts of the body. Scientists have now identified the enzyme that keeps that process in check — and what goes wrong when it disappears.
Ageing cells that refuse to die accumulate in our bodies and cause widespread damage. A new drug can now selectively eliminate them in humans — the first data are in.
A small biotech company is about to test whether ageing cells can literally be ‘rewound’ in living humans. If it works in the eye, it could change medicine forever.
Mitochondria — the energy generators inside our cells — carry their own DNA, separate from the cell’s nucleus.
Fat tissue ages just like the rest of the body. But why does it deteriorate faster in some people?
Nearly half the human genome consists of ancient ‘parasitic’ DNA — sequences that once copied and pasted themselves throughout our chromosomes. In healthy cells they are silenced.
Mitochondria have long been known as the cell’s energy generators. But new research published in Science reveals they also control how effectively your immune system attacks tumors — and that changes everything…
From a vital aging research database that risks disappearing for lack of funding, to promising animal experiments with plasma exchange and thyroid intervention — March 2026 offered a wide range of developments…
Body fat has a reputation problem — but it also ages, and often faster than the rest of us.
Proteins are fragile. Heat, acid, mechanical stress — they deform and fall apart. But a new study shows how combining artificial intelligence with classical chemistry can produce a protein scaffold so robust…
Two of the most well-known genetic risk factors for Parkinson’s disease both disrupt the same cellular process: waste disposal.
Parkinson’s disease begins in the power plants of cells. Researchers have now found a way to deliver healthy versions of those power plants directly into diseased neurons — packaged inside an unexpected…
Fat tissue ages. That much has been known for a while. But what drives the aging process inside individual fat cells has remained murky.
A biotech company targeting so-called zombie cells — cells that stop dividing but refuse to die and instead damage surrounding tissue — has shown for the first time that its approach appears…
Spinal disc degeneration affects almost everyone as they age and is a leading cause of chronic back pain.
Brief exposure to Yamanaka factors can reset cells epigenetically toward a younger state. In mice, the results are striking.
Frailty in older adults — the combination of muscle loss, fatigue, and heightened vulnerability — has no effective treatment.
Animal studies confirm that high doses of nanoplastic particles cause tissue dysfunction.
People are living longer. They are not necessarily living better. The Buck Institute for Research on Aging has announced a new initiative specifically aimed at measuring and extending the years of life…
Senolytics — drugs that selectively eliminate aged, dysfunctional cells — are among the most closely watched interventions in aging research. Until now, the leading candidates have been synthetic compounds.
A biotech company targeting senescent cells has reported positive preliminary results from its first human trial.
Transplanting mitochondria into living cells has long seemed more fantasy than medicine.
Cellular senescence has become one of the most active frontiers in longevity science.
Senolytics — drugs that selectively eliminate aged, dysfunctional cells — are among the most closely watched interventions in aging research. Until now, the leading candidates have been synthetic compounds.
The hunt for safe senolytics — drugs that selectively eliminate aged, dysfunctional cells — has largely focused on repurposed cancer medications.
People are living longer. They are not necessarily living better. The Buck Institute for Research on Aging has announced a new initiative specifically aimed at measuring and extending the years of life…