Exercise damages your cells. But that damage is precisely what makes you healthier. A protein called HMGB1 appears to be the key to that paradox.
Organs do not age in isolation. As kidney function drops, the rest of the body follows. New research maps how renal decline and physical frailty reinforce each other in older adults.
The standard advice of 150 minutes of exercise per week may be seriously undershooting the mark.
A protein best known from cancer research turns out to play a key role in brain aging.
Tendons heal poorly. They have limited blood supply, repair slowly, and in older adults that repair is even slower.
Sound waves directed at the abdomen seem like an unlikely tool for improving muscle function.
A scan of the retina can reveal more than eye health. New research shows that an aging clock based on retinal images correlates with the progression of bone loss (osteoporosis) in older…
Exercise improves metabolism in dozens of ways, but pinpointing which molecule causes which benefit is genuinely hard.
Older mice with elevated levels of a single protein grew stronger, more energetic, and had healthier bones. Their untreated peers declined as expected.
Critics have warned that GLP-1 drugs strip away more muscle than ordinary dieting. A new study puts that concern in perspective.
Muscle stem cells in older animals struggle to activate. A new study pinpoints the reason: a specific metabolic pathway fueled by glutamine quietly shuts down with age.
People in excellent physical condition score almost identically to sedentary peers on most mainstream epigenetic aging clocks. That reveals a fundamental limitation in how these tools are built.
Scientists studying aging face one persistent obstacle: it takes a long time for animals to grow old. An unlikely solution is gaining serious attention — microgravity.
A compound from traditional herbal medicine activates pathways in mice that closely resemble the biological effects of physical exercise. But the gap between mouse data and human benefit remains wide.
Exercise is the best-supported intervention against aging. But what if a plant compound could activate the same signals inside cells?
Astronauts returning from space look as though they have aged by years. That is not coincidence.
Creatine is usually thought of as a supplement for young athletes. But a new study suggests its real potential may lie in older adults — when combined with a specific type of…
Muscle loss in older age isn’t just about inactivity or poor diet. The junctions where nerves tell muscles to work are quietly deteriorating — and new research suggests targeted light treatment could…
Age-related muscle loss has long been blamed on stem cells that simply wear out over time.
Bones were long treated as passive and slow — structure, not biology. New techniques are changing that, enabling targeted manipulation of bone tissue and opening the door to treatments for osteoporosis, fractures,…
Ghrelin is best known as the hormone that makes you feel hungry. But it also plays a role in how muscles age.
In a mouse model of spinal disc degeneration, a cheap, decades-old drug combination beat a newer and more expensive competitor.
Older adults who exercise regularly have measurably different gut bacteria than those who don’t.
Rapamycin is widely considered the leading drug candidate for slowing aging — but a new study suggests it may undercut the health gains from physical exercise in older adults.
Periodic fasting has been promoted for years as a powerful way to improve metabolism. But how the body actually responds differs sharply between organs.
Ghrelin is best known as the hormone that makes you hungry. Less well known is that it also appears to undermine muscle health as we age.
As people age, their risk of joint inflammation rises — not just because joints wear down, but because the body quietly loses one of its own braking systems.
Everyone knows that fit people live longer and get sick less often. But proving that exercise actually causes that better health — rather than the other way around — turns out to…
Sitting still in intense heat turns out to do something the body normally reserves for physical exertion.
As people age, they steadily lose muscle mass — and a hormone best known for triggering hunger may be making things worse.
A small group of fish — including tuna and swordfish — can keep their muscles warmer than the surrounding water. In warming oceans, that remarkable ability is becoming a dangerous liability.
A single half-hour sauna session is enough to temporarily spike the number of white blood cells circulating in the body.
Cartilage heals slowly even in young people, but in older age that capacity nearly disappears.
Topping up a single supplement helps a little. But what if you also stopped the leaking?
King penguins moved from the wild to a zoo get all the food they want and never have to work for it.
Gout has long been typecast as an affliction of older, wealthy men. But it’s now appearing earlier in life, in more diverse populations, and its biological mechanisms are proving more complicated than…
Worn-down spinal discs are behind much of the back pain that becomes nearly universal with age.
Back pain from worn-down spinal discs is one of the most common complaints in aging adults.
Cartilage is one of the body’s least regenerative tissues. Now researchers have found it carries a built-in molecular brake against its own destruction — one that appears to fail precisely when it…
Spinal disc degeneration is one of the most common causes of chronic lower back pain in older people — and so far, there is little to offer beyond painkillers and surgery.
Spinal disc degeneration affects almost everyone as they age and is a leading cause of chronic back pain.
Frailty in older adults — the combination of muscle loss, fatigue, and heightened vulnerability — has no effective treatment.