A gene that barely registers outside research labs turns out to significantly extend the lifespan of fruit flies. And it does so by improving how mitochondria work.
Exercise damages your cells. But that damage is precisely what makes you healthier. A protein called HMGB1 appears to be the key to that paradox.
A little-known protein has been shown to extend the lifespan of fruit flies by improving how their cells produce energy.
Mitochondria, the energy-producing structures inside cells, decline with age. New research identifies a specific lipid molecule as a likely culprit: phosphatidylcholine, the most abundant fat in mitochondrial membranes, drops significantly as organisms…
Exercise improves metabolism in dozens of ways, but pinpointing which molecule causes which benefit is genuinely hard.
Metformin has been the most prescribed type 2 diabetes drug for decades. New research now shows it also inhibits cancer cells through a specific component of the cell’s energy-producing machinery.
Older people often say time seems to pass faster than it used to. A new theory links this to a concrete mechanism: the energy deficit in aging cells.
When a key energy-producing protein is reduced in cancer cells, the tumors don’t slow down — they accelerate. New research reveals a metabolic paradox at the heart of cancer biology.
Naked mole rats live thirty years. Ordinary mice barely manage two. The answer to that gap may not lie in the big picture of biology, but in the smallest working parts of…
Mitochondria — the structures inside every cell that generate energy — are known to decline with age. What is less understood is why.
Suppressing IGF-1, a growth signaling pathway that has been studied for decades as a key to longer life, barely extends lifespan in mice with heavily damaged mitochondria.
A salamander loses a leg and grows it back. We lose a fingertip and it’s gone forever.
Cells are wrapped in a thin membrane made mostly of fat. For decades, that membrane was treated as a passive scaffold.
A molecule central to how cells make energy drops sharply as we age. Scientists have known for years that supplements can partially restore it.
Mitochondria have their own DNA, and errors in it accumulate as we age.
Fat tissue ages faster than most other parts of the body. Scientists have now identified the enzyme that keeps that process in check — and what goes wrong when it disappears.
Mitochondria — the energy generators inside our cells — carry their own DNA, separate from the cell’s nucleus.
Mitochondria have long been known as the cell’s energy generators. But new research published in Science reveals they also control how effectively your immune system attacks tumors — and that changes everything…
Body fat has a reputation problem — but it also ages, and often faster than the rest of us.
Two of the most well-known genetic risk factors for Parkinson’s disease both disrupt the same cellular process: waste disposal.
Parkinson’s disease begins in the power plants of cells. Researchers have now found a way to deliver healthy versions of those power plants directly into diseased neurons — packaged inside an unexpected…
Fat tissue ages. That much has been known for a while. But what drives the aging process inside individual fat cells has remained murky.
Senolytics — drugs that selectively eliminate aged, dysfunctional cells — are among the most closely watched interventions in aging research. Until now, the leading candidates have been synthetic compounds.
Transplanting mitochondria into living cells has long seemed more fantasy than medicine.
Senolytics — drugs that selectively eliminate aged, dysfunctional cells — are among the most closely watched interventions in aging research. Until now, the leading candidates have been synthetic compounds.