longevitywatch

Does retinol help against wrinkles?

Yes · Moderate evidence

Retinol demonstrably works against wrinkles and improves skin texture, although tretinoin is more powerful for those who can or want to obtain a prescription; people troubled by irritation may consider bakuchiol as an equally effective alternative based on one small study.

Topical retinol, a form of vitamin A that you apply to the skin, demonstrably reduces fine lines and wrinkles and improves skin texture. It also increases the thickness of both the outer and deeper layers of the skin. Most studies have been carried out in people with sun-damaged skin, also known as photoageing. For purely age-related wrinkles without sun damage, the evidence is therefore somewhat less extensive.

Retinol is not the most powerful product in its class. Tretinoin, also a retinoid but available only on prescription, is considered the clinical gold standard for topical skin rejuvenation. It is more thoroughly studied and more powerful in its effects, but it also causes more side effects. Retinol is therefore a less powerful but freely available alternative, offering a more favourable side-effect profile as a compromise.

A well-known drawback of retinol is skin irritation: burning, flaking, and sometimes dermatitis are common side effects. Although retinol is less irritating than tretinoin and tazarotene, these complaints can still cause people to stop using it. Building up the concentration slowly can help with this.

If you have sensitive skin or do not tolerate retinol well, bakuchiol is a plant-based alternative. In a study in people with 44 participants over 12 weeks, both bakuchiol and retinol clearly reduced wrinkle area, and neither performed better than the other. People using retinol did experience more flaking and burning. One case of a skin reaction has been reported with bakuchiol, and more research is needed to confirm its effects properly.

The evidence
6 studies · 1 randomised trial · ≈ 44 participants

Claims based on PMIDs 38002296, 18046911, 37903073, 39108105, 29947134, and 36176207. The bakuchiol-versus-retinol study had only 44 participants and lasted 12 weeks, which limits how broadly the findings can be applied. No combined analyses of many studies were used as a direct source; the evidence is strongest for tretinoin, and moderate for retinol and bakuchiol.

Last checked: September 2026 · how this was judged
Related answers

What is the best-proven remedy for wrinkles: retinol or vitamin C?

Tretinoin (prescription vitamin A) has the best evidence against sun-related wrinkles; a cream containing 5% vitamin C showed positive results after 6 months in one study, but has been far less studied. If you have sensitive skin or no prescription, over-the-counter retinol or vitamin C are realistic alternatives.

Strong evidence

Can using too much retinol actually damage your skin?

Cosmetic retinol causes no demonstrable skin damage at normal use levels, though irritation can occur. Stronger prescription retinoids measurably affect the skin barrier and should be used under medical supervision.

Moderate evidence

Can your skin get used to retinol so that it stops working as well?

Your skin gets used to the side effects of retinol, such as flaking and redness, but not to the effect itself; the beneficial effect on fine lines and pigmentation does not diminish with continued use.

Does taking collagen supplements actually work against wrinkles?

Hydrolysed collagen reduces wrinkles and can improve hydration and elasticity. Take 2.5 to 5 grams per day for at least 8 to 12 weeks, and choose a product with 'collagen peptides' or 'hydrolysed collagen' on the label. Marketing promises about spectacular skin rejuvenation are exaggerated.

Yes · Moderate evidence

Does microneedling work for wrinkles and scars?

Microneedling demonstrably works for wrinkles and acne scars, with radiofrequency microneedling being the variant with the strongest evidence base. Combining it with PRP can enhance results, but make sure you are well informed about side effects and choose an experienced practitioner.

Yes · Moderate evidence

Does drinking lots of water really help against dry skin and wrinkles?

Drinking more water has no proven effect on wrinkles and does very little for dry skin. A moisturising cream is a better choice, and make sure you are not chronically underhydrated for your overall health.

No · Preliminary evidence
Related research
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