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Answers to the questions you ask yourself about healthy aging.

336 answers • 2,214 studies
What readers look for answers to
Does coffee activate mTOR?Will a doctor prescribe rapamycin?Can anyone take rapamycin?Is rapamycin hard on the liver?Does rapamycin improve skin aging?Does creatine affect dopamine levels?
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Brain & memoryMemory, dementia and what keeps your brain healthy as you age.
  • Does creatine affect dopamine levels?
  • How does creatine improve mood and well-being?
  • Does creatine supplementation reduce brain fog?
  • Does gratitude or optimism help your health and longevity?
34 answers · 208 studies
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Nutrition & preventionWhat food, fasting, fibre and supplements really do for healthy aging.
  • What are the Blue Zones and how much truth is there to them?
  • Which foods or supplements keep your blood vessels healthy?
  • Can you delay menopause with lifestyle or diet?
  • What causes age spots and can you prevent them?
79 answers · 525 studies
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Muscles & movementStrength training, protein and movement to stay strong and mobile.
  • Does creatine speed up muscle recovery?
  • Does walking in green spaces or nature benefit your health?
  • What is AMPK and how do you activate it (through fasting or exercise)?
  • Why is it harder for me to lose weight than it used to be?
43 answers · 286 studies
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All topics
InterventionsRapamycin, metformin, GLP-1 and other widely-discussed compounds.
  • Does coffee activate mTOR?
  • Will a doctor prescribe rapamycin?
  • Can anyone take rapamycin?
99 answers · 660 studies
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Heart & vesselsCholesterol, blood pressure and vascular age , the biggest cause of death.
  • Is an ECG from your smartwatch actually useful?
  • Which foods or supplements keep your blood vessels healthy?
  • How much does a consistent sleep schedule actually matter?
53 answers · 362 studies
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MetabolismBlood sugar, insulin and weight , the engine of aging.
  • Does coffee activate mTOR?
  • Chronic sleep deprivation: how harmful is it for weight and hormones?
  • What is AMPK and how do you activate it (through fasting or exercise)?
34 answers · 235 studies
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HormonesTestosterone, menopause and hormone therapy as you age.
  • Do black cohosh or red clover help against hot flushes in menopause?
  • Can you delay menopause with lifestyle or diet?
  • What helps against menopause symptoms like hot flushes and mood swings?
24 answers · 166 studies
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SleepHow much sleep you need and what poor sleep does.
  • Chronic sleep deprivation: how harmful is it for weight and hormones?
  • Does stopping coffee in the afternoon really help my night's sleep?
  • How much does a consistent sleep schedule actually matter?
23 answers · 148 studies
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Aging clocksBiological age, epigenetic clocks and biomarkers of aging.
  • What does the stress hormone cortisol do to my ageing?
  • Can you have your telomeres measured, and is there any value in doing so?
  • Do I inherit my life expectancy from my parents?
21 answers · 124 studies
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CancerScreening, lifestyle and what shapes your cancer risk.
  • Does niacinamide (vitamin B3) visibly benefit your skin?
  • Does stress really lower my immune defences?
  • Can long-term inflammation in your body cause cancer?
20 answers · 132 studies
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Immune systemInflammation, defence and how your immune system ages.
  • Can anyone take rapamycin?
  • Does fasting reset your immune system?
  • Does vitamin C actually help against a cold?
20 answers · 132 studies
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Cells & DNATelomeres, mitochondria, senescence and NAD , aging at the cellular level.
  • What is hormesis (what does not kill you makes you stronger)?
  • Do sirtuins actually do anything against ageing?
  • What is mTOR and why does it matter in ageing?
18 answers · 129 studies
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SkinSkin aging and what actually helps against it.
  • Does rapamycin improve skin aging?
  • Does collagen help your joints and your skin?
  • What causes age spots and can you prevent them?
17 answers · 122 studies
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BonesBone density, osteoporosis and strong bones in later life.
  • Can adults still build bone mass, or only maintain it?
  • What do bone-loss medications (bisphosphonates) do, and are they safe?
  • Do men get osteoporosis too?
16 answers · 111 studies
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Gut & microbiomeGut flora, fibre and fermented foods.
  • Is my gut flora linked to being overweight?
  • Does eating a high-fibre diet help with constipation as you get older?
  • Does my gut microbiome change as I get older, and does it matter?
14 answers · 96 studies
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