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Rapamycin, metformin, GLP-1 and other widely-discussed compounds.
352 answers, from 2,523 studies
Last updated: October 2026
Key questions
Do goji berries help against ageing?
Goji has shown interesting properties in experiments with cells and in animal studies. In people, its effect on ageing has…
Preliminary evidence
What do we know about PCC1 from grape seeds against ageing?
PCC1 shows in mouse studies that it can clear out aged and damaged cells. There are no studies in people yet.
Can nucleotides lower your biological age?
NAD+ supplements measurably raise NAD+ levels in your blood and, in one study, prevented biological age from rising, but did…
Preliminary evidence
What are the health benefits of forest bathing?
Walking in the forest regularly measurably reduces anxiety, low mood, and stress. There are positive signals for blood…
How much do cholinesterase inhibitors help with cognitive decline in Alzheimer's?
In mild to moderate Alzheimer's disease, these medications measurably slow cognitive decline. The benefit is modest: side…
Strong evidence
Is there a treatment in development that prevents Alzheimer's?
There are promising indications that an active lifestyle and treatment of risk factors such as high blood pressure and…
Which health interventions really have a big impact?
Exercise and stable housing for homeless people have the strongest evidence base; antidepressants demonstrably work for severe…
Moderate evidence
How do you recognise and treat thyroid problems?
Blood tests give a clear picture of thyroid problems, and levothyroxine works effectively when there are clear abnormalities.…
Moderate evidence
Which supplements are worthwhile after forty?
A few supplements have reasonably solid backing after forty: calcium plus vitamin D for bone protection, B vitamins and a…
Moderate evidence
Does "compound x" help against Parkinson's disease?
"Compound x" is not the name of a single known substance. Several substances show promising results for Parkinson's disease in…
Preliminary evidence
When should you take magnesium for sleep?
Take magnesium about an hour before bedtime, but do not expect a guaranteed effect: the evidence is thin and a substantial…
Preliminary evidence
What is the best way to use creatine?
Creatine works best in combination with strength training: optionally start with a loading phase of 20 grams per day for 5…
Strong evidence
What does creatine monohydrate do for your health?
For strength and muscle mass during high-intensity training, creatine monohydrate (3 to 5 g per day) has the strongest…
Which antioxidants have been proven to be beneficial?
Vitamin E has the best evidence base, particularly for asthma in children. For most other applications the indications are…
Preliminary evidence
Why does magnesium work for some people but not others?
Whether magnesium works for you depends strongly on which form you take and how high your dose is. Preferably choose an…
What does a NAD supplement do, and does it work in people?
NAD supplements demonstrably raise NAD levels in your blood, but whether you actually benefit from that remains uncertain. If…
Preliminary evidence
Does an ice bath work as well for women as it does for men?
An ice bath cools men and women equally quickly in cases of heat stroke, but whether the effect on muscle recovery is equally…
Preliminary evidence
What is an ice bath good for?
An ice bath helps athletes after hard training: less muscle soreness, faster recovery of explosive power, and a reduced sense…
What does regular sauna use do to your immune system?
Regular sauna use produces measurable changes in your immune system, but whether it actually makes you get sick less often has…
What does creatine do in your body besides building muscle?
Creatine does more in the brain than in the muscles: it buffers energy and protects the brain against stress such as sleep…
What should you look out for when buying electrolytes?
For endurance exercise lasting longer than an hour and a half, a drink containing sodium and carbohydrates is worthwhile; for…
Moderate evidence
How many grams of creatine per day is worthwhile?
For muscle strength and explosive performance, 3 to 5 grams of creatine monohydrate per day has a clear effect; a loading…
Moderate evidence
How much magnesium glycinate can you safely take per day?
In Europe the limit is 250 mg of elemental magnesium per day from supplements (350 mg in the United States), although more…
Preliminary evidence
What exactly does magnesium glycinate do in your body?
Magnesium glycinate is well absorbed, but for most healthy people it is not demonstrably better than citrate. For those with…
Can magnesium glycinate cause diarrhoea or gastrointestinal complaints?
At normal doses (around 5 mg per kilogram of body weight per day) gastrointestinal complaints are not to be expected, but at…
Preliminary evidence
Does yoga with meditation reduce DNA damage?
There are early positive indications that yoga with meditation reduces DNA damage, but the evidence is still too limited for…
Preliminary evidence
Do GLP-1 medications help with Parkinson's disease?
GLP-1 agents are showing preliminary positive signals on motor decline in Parkinson's disease, but the studies are still too…
Preliminary evidence
Does extra salt help with fatigue during fasting?
Baking soda (sodium bicarbonate) reduced fatigue in trained men who had fasted and then exercised, but this was found in only…
Preliminary evidence
Does a lithium deficiency increase the risk of dementia?
People in areas with higher lithium levels in drinking water develop dementia less often, but whether a deficiency actually…
Preliminary evidence
Can GLP-1 agonists reduce cravings for alcohol and nicotine?
There are serious indications that GLP-1 agonists such as semaglutide can curb cravings for alcohol and nicotine, but clinical…
Preliminary evidence
Do GLP-1 agonists have a neuroregenerative effect on nerve cells?
GLP-1 agonists show strong indications of protective and restorative effects on nerve cells in animal research, but results in…
Do GLP-1 agonists increase the risk of gallstones and pancreatitis?
GLP-1 agonists measurably increase the risk of gallstones, but the risk of pancreatitis does not appear to be elevated in the…
Moderate evidence
Do GLP-1 medications cause suicidal thoughts?
The available research gives no indication that GLP-1 medications cause suicidal thoughts; several large studies actually…
No · Moderate evidence
Can GLP-1 agonists improve heart function?
Semaglutide and tirzepatide demonstrably reduce the chance of heart failure worsening in people with a specific form of heart…
Yes · Strong evidence
What is so-called 'Ozempic face' and how does it develop?
Rapid weight loss from semaglutide affects the face too: fat beneath the skin disappears, collagen decreases and the skin…
How do you safely taper off Ozempic?
Whether gradual tapering is better than stopping abruptly is not yet known, but stopping abruptly leads to weight regain and…
Preliminary evidence
What are the side effects of Ozempic?
Semaglutide causes digestive complaints, mainly nausea, in one in four users; these usually resolve over time. Rarer signals…
What is the effect of Ozempic combined with alcohol use?
Semaglutide reduces the craving for alcohol and the number of heavy drinking episodes in people with an alcohol use disorder.…
Does Ozempic help with weight loss and how does it work?
Semaglutide demonstrably helps with weight loss: an average of 15% of starting body weight after just over a year. It works by…
Strong evidence
What are effective ways to lose weight?
The combination of eating fewer calories and exercising for more than 250 minutes per week is the most proven effective…
Strong evidence
What are the best ways to fall asleep more easily?
Cognitive behavioural therapy for insomnia works best and lasts longest; sleeping pills are a short-term solution and are even…
Strong evidence
How do you train your memory effectively?
Memory can be trained, but the smartest investment is regular exercise: that has the strongest and broadest support for…
Moderate evidence
How do you protect yourself against tick bites?
Protective clothing, DEET on the skin and a thorough tick check after going outdoors together form a sensible strategy. If you…
Moderate evidence
Does paracetamol help with muscle soreness?
Paracetamol probably does not relieve exercise-induced muscle soreness any better than a placebo, and there are indications…
No · Moderate evidence
What are normal hormone levels for women, and how do you get them tested?
There is no universal standard for hormone levels in women: they depend on age, cycle phase, and measurement method. Always…
Moderate evidence
Does snail slime help reduce scars?
Snail slime shows promising properties for skin repair in the laboratory, but there is as yet no clinical evidence that it…
Preliminary evidence
How do you use peptides for the best results?
For most peptide supplements that you simply swallow, absorption into the bloodstream is so low that little benefit can be…
Preliminary evidence
How early should you start lowering your LDL cholesterol?
Starting as early as possible pays off: LDL damage accumulates from childhood, and every year that your LDL remains lower…
Strong evidence
Can semaglutide slow down the ageing process?
There are early encouraging signs that semaglutide may be able to slow biological ageing, but the clinical evidence comes from…
Preliminary evidence
What does the thymus do, and can you rejuvenate that organ?
The thymus is indispensable for a well-functioning immune system, but inevitably shrinks with age. How this can be…
Moderate evidence
Which supplements are risky in the presence of kidney damage?
Yes, multiple supplements are demonstrably risky in the presence of kidney damage. Herbal preparations (particularly those…
Moderate evidence
Is it better to take a cold bath before or after strength training?
Avoid taking a cold bath immediately AFTER strength training if muscle growth is your goal: it measurably inhibits muscle…
Moderate evidence
Does the sauna help with weight loss?
The sauna makes you sweat, not slim: the weight loss is temporary fluid loss that disappears as soon as you drink again. If…
No · Moderate evidence
Can stem cell therapy slow down or cure rheumatoid arthritis?
Stem cell therapy may be able to slow the symptoms of rheumatoid arthritis, but it does not cure it. The research is still too…
Preliminary evidence
Is retinol safe to use after microneedling?
Whether retinol is safe to use directly after microneedling has not been directly studied. Discuss the timing and dosage with…
Preliminary evidence
How safe are stem cell treatments at foreign clinics?
Unregulated stem cell treatments at foreign clinics carry real risks, including infections, tumour formation and financial…
Moderate evidence
Does the protein GDF11 rejuvenate old cells?
GDF11 rejuvenates certain tissues in mice, particularly the heart, but whether this works in humans has not yet been…
Preliminary evidence
Does stem cell therapy work against ageing in humans?
For physical frailty in older adults there is one positive study in people. For all other ageing-related applications it is…
Preliminary evidence
Can mesenchymal stem cells help with frailty in older adults?
Mesenchymal stem cells appear safe in the short term for frail older adults and do reduce certain markers of inflammation in…
Preliminary evidence
Can stem cell therapy slow down ALS?
Stem cell therapy has not yet been proven effective in ALS patients; the procedure appears to be safely feasible, but whether…
Preliminary evidence
Does semaglutide as a pill work just as well as the injection?
For weight loss, the pill (25 mg daily) and the injection (2.4 mg weekly) are comparably effective. If you have diabetes there…
Yes · Moderate evidence
Does magnesium glycinate help you sleep better?
Magnesium may offer some benefit for sleep in certain people who are deficient or have a medical condition, but this has not…
Preliminary evidence
What is the difference between magnesium bisglycinate and magnesium glycinate?
Magnesium bisglycinate and magnesium glycinate are two names for the same supplement. Whether it is absorbed better than…
Does orforglipron, the weight-loss pill, work as well as Ozempic?
Orforglipron works well for blood sugar and weight, but in obesity it is probably less powerful than injectable Ozempic and…
Moderate evidence
Does Ozempic change your brain?
Ozempic demonstrably changes how your brain responds to food and hunger, which is the core driver of the weight loss. Whether…
Does creatine do anything to your immune system?
Creatine influences immune cells via a specific switch, but whether the outcome is favourable or unfavourable depends strongly…
Preliminary evidence
Do screens and too little outdoor light cause short-sightedness?
Screens are probably not the main culprit; too little time outdoors and academic pressure are better-supported causes. Make…
Does reducing inflammation help your heart in the long term?
Targeted treatment to reduce inflammation, particularly with low-dose colchicine, measurably reduces the risk of serious heart…
Yes · Moderate evidence
How much Zone 2 training is right without overloading?
There is no hard universal formula for the right amount of Zone 2 training, but lactate as a control tool (target zone 2-4.5…
Preliminary evidence
How do you prevent and treat migraines?
For a mild attack, start with ibuprofen or paracetamol; for severe attacks, choose a triptan as early as possible in the attack.
Strong evidence
What health benefits do GLP-1 medications offer beyond weight loss?
In type 2 diabetes, GLP-1 medications offer well-supported protection for the heart, blood vessels, and kidneys; there are…
Strong evidence
Does alpha-ketoglutarate work against ageing?
In animal research AKG clearly extends lifespan, but solid evidence in humans is still lacking. Wait for the results of the…
Preliminary evidence
What is urolithin A and does it work?
Urolithin A appears safe and has shown a modest effect on muscular endurance in some studies, but the hard endpoints fell just…
Moderate evidence
What does quercetin do in your body?
Quercetin has interesting properties in the lab and in small human studies, but whether supplements actually make a difference…
What do we know about berberine patches?
Berberine patches show interesting results in laboratory and animal research for wounds, eczema, psoriasis and joint…
Is berberine safe to use if you are taking medication?
Berberine can influence the blood levels of certain medications, although the clinical significance is unclear in most cases.…
Preliminary evidence
Does berberine help with weight loss?
Berberine leads to modest weight loss in some studies, but a large, well-designed study found no effect on visceral abdominal…
Moderate evidence
What does a study that tests several lifestyle changes at once tell you?
This type of study can reliably measure the effects of several treatments at the same time. Whether the findings can be…
Can you reverse liver fat accumulation and fibrosis?
Early liver fat accumulation and even fibrosis are largely reversible through weight loss of 10% or more. Start with a…
Yes · Moderate evidence
Why do you still get muscle cramps despite taking magnesium?
Magnesium has no demonstrable effect against the most common muscle cramps, neither in older adults nor in athletes. If the…
What are the proven health benefits of snail mucus for the skin?
Snail mucus shows potential in small and preliminary studies for hydration, anti-ageing and wound healing, but large clinical…
What does psilocybin do to your brain health?
Psilocybin shows promising effects on the brain and mood in supervised settings, but the research is still limited and…
What are the differences between ibogaine and psilocybin as treatments?
Psilocybin has more supporting evidence and is safer than ibogaine. Ibogaine carries a real risk of serious, potentially fatal…
What does ibogaine do and what is it used for?
Research shows that ibogaine reduces drug craving and withdrawal symptoms. The heart risks are serious and well documented, so…
Can ibogaine help with Parkinson's disease?
There is no evidence that ibogaine helps with Parkinson's disease, and the known safety risks, particularly for the heart,…
No · Preliminary evidence
What are peptides and how do they work in the body?
Peptides are small protein fragments with a wide range of functions in the body, from hormones to defence substances. As a…
What is the TOTOX value of fish oil supplements?
Many fish oil supplements are more rancid than international standards allow and contain fewer active fatty acids than…
Which supplements are proven to help strengthen bones?
For bone strengthening, the combination of calcium and vitamin D is the best supported by evidence, especially in cases of…
Strong evidence
What can you expect from a longevity clinic in the Netherlands?
A longevity clinic can offer you interesting measurements of your health markers and a good exercise programme. For most…
Preliminary evidence
What does research say about the relationship between lithium and memory?
Lithium slows cognitive decline in mild memory problems and early Alzheimer's disease, but for healthy people or as a…
Can you slow down the ageing of your immune system?
The immune system demonstrably ages, and there are promising avenues for slowing that process, but no single approach has been…
Preliminary evidence
Do probiotics help with irritable bowel syndrome itself, or only when taken alongside antibiotics?
Probiotics reduce IBS symptoms even without antibiotics, with Bacillus coagulans and Bifidobacterium strains having the…
Moderate evidence
What are the effects of microdosing with Ozempic?
Microdosing with Ozempic has not been studied as a weight-loss method; the only small study using low doses shows an effect on…
Does strength training help against osteoporosis just as well as medication?
Strength training demonstrably improves bone density and offers additional benefits that medication does not, but the two are…
Moderate evidence
Do ketone drinks do anything for your brain or performance?
For people with memory complaints the early signals are cautiously positive, but the studies are small and not conclusive. As…
Preliminary evidence
Does hearing loss increase your risk of dementia, and does a hearing aid help?
Hearing loss demonstrably increases the risk of dementia, and a hearing aid appears to help, but proven protection for…
Moderate evidence
Is spermidine from food just as good as a supplement?
There is no evidence that a spermidine supplement does the same thing as spermidine from food; supplements may be neutralised…
No · Preliminary evidence
Does a NAD+ infusion do something that an NMN pill does not?
No study directly compares a NAD+ infusion with an oral NMN pill, so an advantage of the infusion has not been demonstrated.…
Do senolytics already work in humans, or only in mice so far?
Senolytics no longer work only in mice: there is now first concrete evidence in humans, but the studies are small and lack…
Preliminary evidence
What do we know about rapamycin as an anti-ageing agent in humans?
Rapamycin shows measurable improvements in immune function and cellular ageing markers in people. Whether it also extends…
Do you lose muscle mass when losing weight with a GLP-1 medication?
With GLP-1 medications you do indeed lose muscle mass alongside fat, but you can largely limit this by combining resistance…
Moderate evidence
How much berberine do you need per day?
For blood sugar regulation in type 2 diabetes, 500 mg three times daily (1500 mg per day) for at least 8 to 12 weeks is the…
Moderate evidence
How many probiotics do you need per day?
For irritable bowel syndrome, 1 to 4 billion live bacteria per day, maintained for at least four to eight weeks, has been…
Preliminary evidence
How much ashwagandha do you need per day?
Research points to 300-600 mg per day as the effective range for stress, anxiety and athletic performance, but the quality of…
Moderate evidence
How much CoQ10 do you need per day?
There is no established daily dose of CoQ10 for healthy people. The form on the label determines how much your body absorbs: a…
Insufficient evidence
How much iron do you need per day?
For healthy adults without a deficiency, 1 to 2 mg of iron per day through food is sufficient. When a deficiency or anaemia is…
Moderate evidence
What do we really know about metformin and ageing?
In people with diabetes, metformin shows clear health benefits. Whether it also slows ageing in healthy people is being…
Can probiotics improve your health in later life?
Probiotics can make a modest contribution in later life, but which product works best depends on what you want to improve. For…
Yes · Moderate evidence
What can help women increase their libido?
There are several well-supported options depending on your life stage: for women after menopause, transdermal testosterone has…
Moderate evidence
Can clogged blood vessels be cleaned up again?
Early arterial hardening can partly be reversed, especially with strong LDL reduction using statins or newer medicines. The…
Yes · Moderate evidence
What really keeps your mouth and gums healthy?
Daily brushing supplemented with interdental brushes is the best foundation for a healthy mouth; if you have diabetes, regular…
Moderate evidence
Does gene therapy with klotho or follistatin work against ageing?
Klotho gene therapy shows promise in mice and cells, but there are no human data yet. The available sources say nothing at all…
Preliminary evidence
Does mewing really work for a sharper jawline?
There is no clinical evidence that mewing improves the jawline in adults. Serious tongue-exercise therapy does exist, but is…
No · Preliminary evidence
Does an adrenal cocktail actually work?
An adrenal cocktail does not work, because the condition it is supposed to treat does not exist as a recognised diagnosis. If…
No · Strong evidence
Does a vampire facial (PRP) work against skin ageing?
PRP injections produce a modest, probably real improvement in skin texture and elasticity, but do not work for everything…
Yes · Moderate evidence
Does whole-body cryotherapy actually work for your health?
For specific applications, such as pain following knee surgery and possibly improved lipid levels, WBC shows small positive…
Preliminary evidence
Does plasma exchange (plasmapheresis) work against ageing?
There are initial, cautiously positive indications from one small study, but it is too small and too influenced by commercial…
Preliminary evidence
Does a NAD infusion (IV drip) make sense?
A NAD infusion has no proven advantage over cheaper oral supplements, and even those show barely any demonstrable effect in…
No · Preliminary evidence
Does ergothioneine work as a longevity supplement?
Ergothioneine shows a positive signal in a small study of older adults with memory complaints, but it is too early for firm…
Preliminary evidence
Does mouth taping help you sleep better?
For healthy sleepers, mouth taping has not been proven beneficial, and it is risky if you have a blocked nose. If you have…
No · Preliminary evidence
Does nattokinase work against blood clots and for your heart?
The best available research shows that nattokinase has no demonstrable effect on arterial hardening or blood pressure after…
No · Preliminary evidence
Does rosemary oil really work for hair growth?
Rosemary oil has a measurable effect on hormonal hair loss, comparable to minoxidil 2%, but less potent than conventional…
Yes · Moderate evidence
Do gua sha and microcurrent devices work against skin ageing?
Gua sha and facial rollers show initial positive results, but the evidence is thin; microcurrent devices have somewhat more…
Preliminary evidence
Do copper peptides (GHK-Cu) work in skincare?
GHK-Cu shows positive effects on collagen in the lab, but clinical evidence in humans is lacking. Do not expect too much from…
Preliminary evidence
Does snail mucin actually work for your skin?
Snail mucin shows promising effects in laboratory and cell studies, but clinical evidence in humans is still largely absent.…
Preliminary evidence
Does a low dose of lithium help protect the ageing brain?
There are preliminary indications that low doses of lithium may offer brain protection, but the evidence is still too thin and…
Preliminary evidence
Do functional mushrooms like reishi and cordyceps actually work?
Medicinal mushrooms such as reishi show promising effects in the lab, but convincing evidence from studies in people is still…
Preliminary evidence
Does apigenin help you sleep better?
There is currently no evidence that apigenin as a supplement meaningfully improves sleep in humans. Animal research is…
No · Preliminary evidence
Is sea moss (Irish moss) a worthwhile supplement?
As a food, sea moss has a reasonably good nutritional profile, but as a supplement there is no evidence that it provides a…
No · Preliminary evidence
Does shilajit actually work as a supplement?
Shilajit has shown positive results for specific goals, such as testosterone in men aged 45 to 55 and bone healing, but it…
Moderate evidence
Do exosomes in skincare really work?
There are preliminary indications that exosomes may do something for the skin, but the clinical evidence is very thin: one…
Preliminary evidence
Does earthing (grounding) really work for your health?
There are preliminary signs that earthing may improve pain, fatigue and sleep, but the studies are still too small and too…
Preliminary evidence
Do polynucleotide or salmon DNA facial treatments actually work?
There are cautious indications that polynucleotide injections may improve the skin around the eyes, but well-controlled…
Preliminary evidence
Does calcium-AKG lower your biological age?
Reliable evidence that calcium AKG lowers biological age in humans is lacking. The well-known claim of 8 years comes from a…
Preliminary evidence
Does lion's mane really work for your brain?
Lion's mane shows cautiously positive signals for attention and working memory in small studies, but the evidence is still too…
Preliminary evidence
Is colostrum (beestings) a worthwhile supplement?
For now, colostrum has the strongest indications as an aid against respiratory tract infections in athletes; for most other…
Preliminary evidence
Does methylene blue really work for energy and brain function?
Do not take this as a supplement. Methylene blue is a registered medicine, not a dietary supplement, and is not permitted as…
Preliminary evidence
Does the Wim Hof method actually work?
There are signs that the method can dampen the body's inflammatory response, but the studies are small, and for stress, mood,…
Preliminary evidence
Does microneedling work for wrinkles and scars?
Microneedling demonstrably works for wrinkles and acne scars, with radiofrequency microneedling being the variant with the…
Yes · Moderate evidence
Does liposomal vitamin C work better than regular vitamin C?
Liposomal vitamin C reaches higher blood levels than regular vitamin C, but whether that translates into real health benefits…
Moderate evidence
Does boron raise your testosterone?
The two randomised studies in men show no effect on testosterone; the only small study that did find a rise in men had no…
No · Preliminary evidence
Does taking glycine help you sleep better?
Glycine shows tentatively positive signals, but the evidence is thin and the only direct human study comes from the…
Preliminary evidence
Does tongkat ali actually work for your testosterone?
Do not use it, even though it probably does raise your testosterone. The European food safety authority EFSA found signs that…
Yes · Moderate evidence
Is ubiquinol better than regular CoQ10?
Ubiquinol is not automatically better than regular CoQ10: the formulation, such as soft-gel or water-soluble, matters more…
Moderate evidence
Does St. John's wort affect how your medications work?
St. John's wort lowers the blood levels of dozens of medications and can have serious consequences, such as transplant…
Yes · Strong evidence
Which supplements are best avoided in combination with blood thinners?
Several supplements can strengthen or weaken the effect of blood thinners; always mention them to your pharmacist or doctor…
Preliminary evidence
Should you take extra copper when taking high doses of zinc?
Anyone who takes more than 25 mg of elemental zinc per day over a prolonged period runs a real risk of copper deficiency,…
Yes · Moderate evidence
Is it better not to take iron and calcium together?
For healthy people without medication, strictly separating intake is probably unnecessary, as long-term research shows no…
Moderate evidence
When is the best time to take fisetin?
There is no human research identifying an optimal time to take fisetin. What the available animal research makes clear is that…
Preliminary evidence
Does creatine put a strain on your kidneys?
For healthy people without kidney disease, creatine monohydrate at normal doses is not harmful to the kidneys, although it can…
No · Moderate evidence
Is ashwagandha safe for your liver?
For healthy people the risk of liver injury appears small, but it is not negligible. If you have a liver condition, do not use…
Moderate evidence
Can you get too much vitamin D?
Too much vitamin D is genuinely harmful, but that risk only arises at blood levels far above the recommended values. Stick to…
Yes · Moderate evidence
Can you take too much magnesium?
Yes, too much magnesium can be dangerous, although serious toxicity through ordinary supplements is rare in people with…
Yes · Moderate evidence
Do you need to do a loading phase with creatine?
A loading phase is not necessary, but it does speed up the build-up of creatine in your muscles. Choose a loading phase if you…
No · Moderate evidence
How much curcumin should you take per day?
There is no fixed 'correct dose' of curcumin: for joint pain, less than 1000 mg per day works just as well as more, but for…
Preliminary evidence
Is magnesium L-threonate better for your brain?
MgT has preliminary indications that it raises brain magnesium more effectively and may support cognition, but the human…
Preliminary evidence
Which form of vitamin B12 is best to take?
The form of vitamin B12 matters less than the dose: when correcting a deficiency, what counts above all is taking enough. When…
Preliminary evidence
Does eating less help you live longer?
In laboratory animals the effect on lifespan is well established, but in healthy humans direct evidence is lacking. A moderate…
Moderate evidence
Is pterostilbene better than resveratrol?
Pterostilbene is absorbed better than resveratrol and more often outperforms it in laboratory and animal studies, but it has…
Preliminary evidence
Does taking glutathione make sense, or is it broken down in your gut?
Oral glutathione measurably raises levels in blood and cells, so it is not entirely pointless. Whether that rise translates…
Moderate evidence
Which is better for raising NAD+: NMN or NR?
NMN and NR raise NAD+ equally well, so the choice between the two probably makes no difference to the end result. Whether that…
Moderate evidence
Is it better to take ashwagandha in the morning or in the evening?
More important than the timing: several regulators, including the RIVM, advise against ashwagandha because of risks to the…
Insufficient evidence
Which type of collagen is best to take?
For the skin, hydrolysed collagen peptides (2.5 to 5 grams per day for at least 8 to 12 weeks) are the best-supported option.…
Moderate evidence
Which form of zinc is best to take?
Zinc picolinate and zinc histidine have the strongest independent evidence for good absorption, but all comparative studies…
Preliminary evidence
Is creatine monohydrate just as good as more expensive forms?
Creatine monohydrate works at least as well as more expensive alternatives and is the most thoroughly documented safe choice.…
Yes · Moderate evidence
Is curcumin well absorbed by your body?
Ordinary curcumin without any addition is barely absorbed by the body; choose a product with piperine (black pepper extract)…
No · Moderate evidence
Which form of magnesium is best to take?
Magnesium citrate has the strongest evidence for absorption into the body. Magnesium oxide, the cheapest option, demonstrably…
Moderate evidence
Is intermittent fasting good for longevity?
Intermittent fasting improves health markers such as weight and insulin sensitivity, but whether it also makes you live longer…
Moderate evidence
Do you really need calcium supplements for strong bones?
Whether you need calcium supplements depends strongly on your age and situation: for healthy women before the menopause there…
Moderate evidence
Does fasting help your cells clean themselves up?
Fasting demonstrably increases the self-cleaning function of your cells, but watch out for muscle breakdown during prolonged…
Yes · Moderate evidence
Why do some cells stop dividing as you age?
Cells stop dividing because their chromosome tips wear down and they accumulate DNA damage: a protective mechanism that in…
What do zombie cells do to your ageing?
Zombie cells accumulate as you age and accelerate ageing through inflammatory signals; how to tackle them is promising but…
Why do older adults become seriously ill from an infection more quickly?
Ageing weakens the immune system in several ways simultaneously, making infections more dangerous. Keep vaccinations up to…
Does the flu shot work less well as you get older?
The flu shot demonstrably works less well in older adults than in younger people, but high-dose and other improved vaccines…
Yes · Strong evidence
What is the lower limit for vitamin B12 values?
There is no single universal lower limit for vitamin B12: it differs by measuring device, ethnicity, and life stage. Always…
What is the best way to measure vitamin B12?
Total B12 alone misses too many cases. Ideally combine it with MMA (methylmalonic acid, a substance that rises when your cells…
What does caffeine do to your cells and their repair processes?
Caffeine inhibits important DNA repair processes while simultaneously having protective effects in certain cell types,…
Can heat, such as a sauna, damage your cells or actually make them stronger?
Moderate heat briefly damages cells, but simultaneously triggers a repair response that makes the cell more resilient.…
Does morning light help you fall asleep more easily in the evening?
A consistent morning routine with daylight helps sharpen your biological clock, allowing you to fall asleep earlier and more…
Yes · Moderate evidence
Why am I wide awake in the evening when I feel tired during the day?
Your biological clock and your chronotype determine when your body wants to be awake. When that clock does not align with your…
Why do some people develop better protection after vaccination than others?
How well you respond to a vaccine depends on your genetic predisposition, age, the condition of your immune system, and any…
Can using too much retinol actually damage your skin?
Cosmetic retinol causes no demonstrable skin damage at normal use levels, though irritation can occur. Stronger prescription…
Moderate evidence
Can meditation do anything about ageing at the cellular level?
Meditation appears to activate an enzyme that protects chromosome caps from ageing, although the studies are still too small…
Yes · Preliminary evidence
Can cognitive behavioural therapy help me sleep better long-term without pills?
CBT-I demonstrably produces lasting sleep improvement, even after the sessions end, something that does not apply to sleep…
Yes · Strong evidence
What does taking the pill for a long time do to your hormones after stopping?
After stopping the pill, your hormone balance generally recovers within a few weeks to months, regardless of how long you have…
Is mineral sunscreen better for your skin than chemical sunscreen?
Mineral sunscreen has a favourable safety profile and tinted varieties may offer additional protection, but it is not…
Moderate evidence
Does red light therapy really have an effect on your cells?
Red light therapy has a biologically plausible effect on cells, with positive clinical indications for pain and recovery, but…
How reliable is a saliva test for biological age?
A saliva test provides a reasonable estimate of your calendar age, but does not measure exactly the same thing as a blood test…
Does a blue-light filter on my phone actually affect my sleep?
A blue-light filter on your phone probably has little effect on your sleep; if you still want to try something, filter glasses…
No · Preliminary evidence
Does melatonin improve sleep in older age?
For older people with sleep complaints, particularly waking up too early, melatonin offers a modest but real benefit. The…
Moderate evidence
Does CBD oil help you sleep better?
There is currently too little good research to say that CBD oil genuinely helps with sleep problems; if you are affected,…
Preliminary evidence
Does red light therapy really help against skin ageing?
Red light therapy shows improvement in skin texture and wrinkles across multiple studies, but the effects are modest and the…
Moderate evidence
Can cold showers make your cells healthier?
Cold showers do not demonstrably make your cells healthier: they actually hold back growth and recovery processes in muscle…
No · Moderate evidence
Does regular sauna use protect your brain against decline?
People who used a sauna four to seven times a week developed dementia considerably less often in long-running research than…
Moderate evidence
Does watching a lot of television affect your brain?
Watching more than 3.5 hours of television per day is associated with faster memory decline in people aged 50 and over,…
Yes · Moderate evidence
Does zinc help with acne and healthier skin?
Zinc demonstrably reduces inflamed pimples, but works less well than benzoyl peroxide or antibiotics. It is most useful if you…
Yes · Moderate evidence
Is reading every day good for your brain in the long run?
Daily reading is associated with a lower risk of dementia and greater cognitive resilience in later life. Whether reading…
Yes · Moderate evidence
Do your brains really shrink as you get older?
Your brain does indeed shrink with age, particularly in areas involved in memory and planning. High blood pressure accelerates…
Does screen time (blue light) age your skin?
Blue light demonstrably damages skin in the laboratory, but whether your screen emits enough blue light to cause that in real…
Preliminary evidence
Can meditation slow your biological clock?
Research shows that meditation has a beneficial effect on telomerase activity, an enzyme that protects cells from ageing. In…
Preliminary evidence
What does a vitamin D deficiency do to your brain?
A vitamin D deficiency is associated with a higher risk of cognitive decline and dementia, but whether correcting it with…
Does a face mask really work, or is it mostly just a treat for yourself?
An LED mask or a mask containing active ingredients such as salicylic acid works measurably better than doing nothing, but the…
Moderate evidence
Does valerian really help you fall asleep faster?
Valerian has not been shown to help people fall asleep faster, but if you want to try it and do not have insomnia as a medical…
No · Moderate evidence
Does aspirin or ibuprofen protect against bowel cancer?
Aspirin demonstrably protects against bowel cancer in people with a hereditary elevated risk (Lynch syndrome) and in people…
Yes · Moderate evidence
Does echinacea really work against the common cold?
Whether echinacea helps with the common cold depends strongly on which preparation you use. Standardised products made from…
Moderate evidence
Can fasting really rejuvenate your cells?
Fasting has clear cell-rejuvenating effects in animal research, but in humans the evidence is still limited to small studies…
Preliminary evidence
Can your skin get used to retinol so that it stops working as well?
Your skin gets used to the side effects of retinol, such as flaking and redness, but not to the effect itself; the beneficial…
Does taking cortisone long-term weaken your bones?
Long-term cortisone use demonstrably weakens your bones; if you use it long-term, it is wise to discuss with your doctor…
How do I know whether my fatigue is caused by my thyroid?
Thyroid blood tests can rule out or confirm whether your thyroid is the cause, but a mildly abnormal TSH alone does not…
Do peptides in skincare actually do anything?
Peptides in creams have a plausible mechanism on paper, but clinical evidence for topical use is thin. If you want to do…
Preliminary evidence
Does beta-glucan help strengthen your immune system?
Beta-glucan demonstrably activates parts of the immune system, but the evidence that a supplement genuinely protects healthy…
Moderate evidence
Does a weighted blanket really help you sleep better?
A weighted blanket may be beneficial for sleep in some people, particularly those with anxiety, autism, or sensory…
Preliminary evidence
Does your skin get thicker or thinner as you age?
Your skin thins at two levels with age: that is well established. Retinoid creams have the most support if you want to slow…
What is a cytokine storm?
A cytokine storm is a life-threatening syndrome in which the immune system reinforces itself in a spiral of inflammation that…
Does using a night face cream actually help?
A retinoid night cream has the best evidence base and can produce visible improvement after three months. For regular…
Yes · Preliminary evidence
What is the difference between probiotics and postbiotics?
Probiotics contain live bacteria; postbiotics work with inactivated micro-organisms or their building blocks. Postbiotics are…
Does the sleep tracking feature on my smartwatch have any value?
Your smartwatch gives a useful indication of your sleep pattern, but accuracy varies considerably by device and it is not a…
Moderate evidence
Should you get tested for hereditary breast cancer?
Breast cancer can be hereditary, and if you recognise multiple cases in your family, it is sensible to discuss this with your…
Yes · Strong evidence
Does magnesium help with insulin resistance?
There is reasonable evidence that magnesium has a beneficial effect on insulin resistance, particularly if your magnesium…
Yes · Moderate evidence
Is a colonoscopy the only way to detect bowel cancer early?
A colonoscopy is not the only way to detect bowel cancer early. Stool-based tests, CT scans and sigmoidoscopy are recognised…
No · Moderate evidence
Does cold showering boost your immune system?
Cold showering does not demonstrably strengthen your immune system in the short term, but people who do it regularly do report…
Moderate evidence
Does bakuchiol work as well as retinol but more gently?
In small studies, bakuchiol shows results comparable to retinol for wrinkles and dark spots while causing less irritation. For…
Yes · Moderate evidence
Can fasting turn back your biological age?
Fasting, particularly intermittent fasting and ketogenic diets, moves multiple biological ageing markers in a favourable…
Moderate evidence
Can a bed that is too warm cause me to sleep worse?
A bed that is too warm disrupts your sleep; a slight drop in body temperature is actually necessary for falling asleep well.…
Yes · Moderate evidence
Does magnesium really help you sleep better?
Magnesium may be worth trying for sleep problems, but the evidence is limited and the studies are partly contradictory. At…
Moderate evidence
How does metformin work in your body?
Metformin lowers blood sugar primarily by causing the liver to produce less new glucose, without the risk of dangerously low…
Does metformin help with weight loss?
Metformin helps with weight loss, but the effect is modest: expect a few kilograms, not a dramatic transformation. Lifestyle…
Yes · Moderate evidence
Can you take metformin without having diabetes?
Metformin has a reasonable evidence base for specific groups without diabetes (prediabetes, PCOS, overweight with insulin…
Moderate evidence
What are the side effects of metformin?
Metformin causes gastrointestinal complaints such as diarrhoea, nausea and vomiting in a substantial proportion of users.…
How often should you have your HbA1c measured?
In stable diabetes, measuring twice a year is standard; when values fluctuate or treatment has changed, four times a year is…
Moderate evidence
How do you lower a high HbA1c?
Several medications demonstrably lower HbA1c: the weekly semaglutide injection has the strongest evidence base, but oral…
Strong evidence
What does autophagy do for ageing and disease?
Autophagy is a genuine part of the ageing process and plays a role in many age-related diseases, but the translation into…
What are the side effects and risks of retatrutide?
Retatrutide causes gastrointestinal complaints in many users and a temporary increase in heart rate; serious side effects were…
Is retatrutide more effective than Ozempic?
Indirect comparisons suggest that retatrutide produces greater weight loss than semaglutide (Ozempic/Wegovy), but the drug has…
Moderate evidence
How many hours of fasting are needed to activate autophagy?
There is no proven hourly threshold for activating autophagy in humans. If you use this as a reason for a fasting pattern, be…
Does creatine help prevent muscle loss with GLP-1 medications like Ozempic?
Whether creatine genuinely helps preserve muscle during GLP-1 medication use is unknown, because it has never been directly…
Preliminary evidence
What is best not to combine with creatine?
Combining creatine with caffeine powder adds nothing to your performance and increases the risk of gastrointestinal…
Moderate evidence
Why don't doctors always recommend creatine?
Creatine monohydrate is well supported for strength sports and its safety profile in healthy adults is reassuring, but safety…
Does creatine cause hair loss?
Current research shows that creatine does not raise DHT and has no effect on hair follicle health. There is no need to avoid…
No · Moderate evidence
Does creatine affect your sleep?
Creatine may improve how you experience your sleep, but objective measurements show no effect. The research is based on dozens…
Preliminary evidence
Is rapamycin found in food, or can you get it naturally through your diet?
Rapamycin is not present in food and cannot be obtained naturally through eating. If you want to learn more about it in the…
At what age does taking NAD+ supplements make sense?
There is no established age at which NAD+ supplementation becomes worthwhile. Studies focus on middle-aged and older adults,…
Preliminary evidence
Which supplements or medications are best not combined with NAD+?
The combination of NAD+ supplements, particularly nicotinamide, with platinum-based chemotherapy is the most concrete reason…
Preliminary evidence
What does NAD+ do for your brain?
NAD+ matters for your brain and declines with age. Whether topping it up via NMN (a substance your body converts into NAD+) or…
Who should have their ApoB measured?
Measuring ApoB is worthwhile for more people than current guidelines suggest: not only in cases of elevated blood fats, but…
Moderate evidence
How do you lower an ApoB level that is too high?
An ApoB level that is too high is very treatable, and several proven agents are available. Statins are the first choice; PCSK9…
Strong evidence
What does your ApoB value tell you about your risk of cardiovascular disease?
ApoB gives a more accurate picture of your cardiovascular disease risk than standard LDL cholesterol. Ask your doctor to also…
Can you lengthen or restore your telomeres?
Healthy adult body cells cannot lengthen their own telomeres, and no proven safe way to do so from the outside yet exists. Be…
No · Moderate evidence
What is the relation between NAD+ and vitamin B3?
Vitamin B3 is the only dietary building block for NAD+ in your body; that relationship is causal and well supported. Whether…
What is the controversy surrounding NAD+?
NAD+ supplements raise your NAD+ levels, but whether that translates into any health benefit has not been proven, and in the…
Does NAD+ supplementation slow biological ageing?
NAD+ supplements reliably raise your blood levels. Whether that also slows biological ageing has not yet been demonstrated in…
No · Preliminary evidence
What are the effects if you take NAD every day?
Taking 600-900 mg of a NAD supplement per day raises your NAD levels and provides some benefit for endurance, but long-term…
Which foods or habits effectively raise NAD+ levels?
Exercise and NAD+ supplements (NR or NMN) demonstrably raise NAD+ levels, but whether higher levels also confer health…
Moderate evidence
Can rapamycin reverse or prevent grey hair?
Rapamycin shows promising effects on grey hair in cell and animal studies, but it has not been tested in people. It is too…
Preliminary evidence
Does coffee activate mTOR?
Coffee does not activate mTOR. Caffeine actually inhibits mTOR, and in humans this mechanism has not yet been directly tested.…
Will a doctor prescribe rapamycin?
Most doctors will not prescribe rapamycin to healthy people to slow ageing, simply because the evidence for doing so is still…
Preliminary evidence
Can anyone take rapamycin?
Rapamycin is a powerful drug with serious side effects, including reduced immune function and blood sugar disturbances, and is…
No · Moderate evidence
Is rapamycin hard on the liver?
Rapamycin itself shows no measurably greater direct liver damage than alternative treatments in studies. The related drug…
Moderate evidence
Does rapamycin improve skin aging?
Topical rapamycin showed promising signs for skin ageing in a small study, but the evidence is still too thin to justify…
Preliminary evidence
Does creatine affect dopamine levels?
In healthy people, creatine has no demonstrable effect on dopamine in the blood. Positive signals so far come exclusively from…
Does creatine speed up muscle recovery?
Creatine (3 to 5 grams per day) can probably speed up muscle recovery after intense training and improve strength and muscle…
Yes · Moderate evidence
How does creatine improve mood and wellbeing?
Small studies occasionally show positive signals in depression, but an international guideline based on many studies concludes…
Does creatine supplementation reduce brain fog?
Creatine may ease cognitive complaints, but the effect depends heavily on your situation: people with chronic fatigue, sleep…
Moderate evidence
What is hormesis (what doesn't kill you makes you stronger)?
Hormesis is a well-described biological principle: a low dose of stress can make your cells more resilient, provided the dose…
What are the Blue Zones, and what is actually true about them?
Blue Zones show a striking pattern of lifestyle and advanced age. The exact age figures are disputed, but regular exercise,…
Moderate evidence
Is an ECG from your smartwatch actually useful?
For detecting atrial fibrillation, a smartwatch ECG can be useful, especially as a complement to medical monitoring. For other…
Yes · Moderate evidence
Do black cohosh or red clover help with hot flushes during menopause?
Red clover may slightly reduce hot flushes; for black cohosh the evidence is contradictory. Both products may be an option if…
Preliminary evidence
What helps against menopause symptoms like hot flushes and mood swings?
Hormone therapy works best against hot flushes and night sweats. Those who cannot or do not wish to use it can choose from…
Strong evidence
What helps against osteoarthritis (joint degeneration)?
Supervised exercise therapy and diclofenac gel have the strongest evidence base in osteoarthritis. Paracetamol and opioids…
Strong evidence
Does fasting reset your immune system?
Fasting lowers inflammatory markers and has measurable effects on the gut microbiome that appear to be beneficial for the…
Yes · Moderate evidence
What is the difference between living longer and living longer in good health?
Healthspan and lifespan are two separate things: you can live a long time yet lose years to illness and decline. Calorie…
Do sirtuins actually do anything against ageing?
Sirtuins play a clear role in ageing in animal research, but whether they are of any benefit to humans (through supplements or…
Preliminary evidence
What is mTOR and why does it matter in ageing?
mTOR is a switch in your cells that determines when they grow and when they clean themselves up. In ageing, that switch is set…
Does my growth hormone decline with age, and does that matter?
Your growth hormone does indeed decline sharply with age. Reversing that with hormone injections offers little benefit in…
Yes · Strong evidence
Is testosterone important for women?
Testosterone is a physiologically relevant hormone for women, with the strongest evidence for sexual desire and sexual…
Does creatine also help with memory and concentration?
Creatine can improve your memory, but mainly if you are older, vegetarian, or your brain is under pressure. If you are a…
Yes · Moderate evidence
Can you repair sun damage to your skin?
Sun damage can be partially repaired: prescription tretinoin cream has the strongest evidence base, but consistent sunscreen…
Yes · Moderate evidence
What do bone-loss medications (bisphosphonates) do, and are they safe?
Bisphosphonates reduce fractures and increase bone density in osteoporosis, and at high fracture risk can be used safely for…
Strong evidence
Do omega-3s help against heart rhythm disorders?
Omega-3 supplements do not help against heart rhythm disorders and at higher doses actually increase the risk of atrial…
No · Strong evidence
What actually helps with chronic lower back pain?
Strength and stabilisation exercises have the strongest evidence base for chronic lower back pain. If those do not help…
Moderate evidence
Can I prevent or slow down early hearing loss?
Hearing loss caused by noise and by certain medications is very preventable, but for age-related hearing loss no proven…
Moderate evidence
How do I keep my kidneys healthy as I age?
The two best-supported steps to limit kidney damage as you age are keeping your blood pressure under control and exercising…
Moderate evidence
Do you live longer on a vegetarian or plant-based diet?
A good-quality plant-based diet is linked to fewer early deaths. But strictly vegetarian or vegan eating has not been proven…
Moderate evidence
Is strength training still safe and worthwhile after the age of 70?
Strength training after 70 is both safe and worthwhile: the evidence for greater muscle strength and reduced fall risk is…
Yes · Strong evidence
Does stretching actually do anything, or is it a waste of time?
Stretching demonstrably improves flexibility, and 10 minutes per week is already enough for the maximum effect. For preventing…
Strong evidence
Does taking vitamin E have any proven benefit?
For the most widely studied application, the heart, vitamin E demonstrably does not work; for skin and fertility the evidence…
No · Strong evidence
Is taking a stack of supplements at the same time dangerous?
Whether a supplement stack is smart or dangerous depends on which substances you combine and whether you also take medicines.…
Moderate evidence
Does the combination of glycine and NAC (GlyNAC) help against ageing?
Early studies in older adults show that GlyNAC can simultaneously improve multiple signs of ageing, from muscle strength and…
Yes · Moderate evidence
Is collagen powder worth it for your joints?
For people with knee osteoarthritis or joint pain during exercise, there is reasonable supporting evidence that collagen…
Yes · Moderate evidence
Does fisetin from strawberries really work as a zombie-cell clearer?
Fisetin demonstrably clears zombie cells in cell experiments and in animals, but whether this also works in people and is safe…
Preliminary evidence
What works better for weight loss: semaglutide or tirzepatide?
Tirzepatide consistently produces greater weight loss than semaglutide, but both medications have comparable gastrointestinal…
Strong evidence
Should you worry about mildly elevated cholesterol?
A mildly elevated cholesterol is not automatically harmless: the overall picture, including triglycerides and lipoprotein(a),…
Moderate evidence
Is atrial fibrillation dangerous, and what can I do about it?
Atrial fibrillation substantially raises your chances of dying, heart failure, and stroke, and calls for active treatment.…
Yes · Strong evidence
How often should I measure my blood pressure at home, and what is normal?
Measuring at home gives a more reliable picture than a single reading at the doctor's office: measure at least seven days,…
Moderate evidence
Do prebiotics work just as well as probiotics?
Prebiotics and probiotics are comparably effective for constipation; for depression and blood sugar, probiotics have a slight…
Preliminary evidence
Is breast cancer screening worth it?
Participating in breast cancer screening may offer a small benefit, but the chance of unnecessary treatment or a…
Moderate evidence
Should I, as a man, be tested for prostate cancer with the PSA test?
Whether the PSA test is worthwhile depends on your personal risk. Men aged 55 to 69 with an elevated risk, such as a family…
Moderate evidence
Can you still reverse early-stage forgetfulness with your lifestyle?
Lifestyle can probably slow early-stage forgetfulness and sometimes partially improve it, but full reversal has not been…
Moderate evidence
Is forgetting names around 50 normal?
Forgetting names around age 50 is normal and biologically explainable. It is not a reason for immediate concern, but exercise…
Yes · Moderate evidence
How big is the difference between your biological and calendar age?
The typical spread between your biological and calendar age is around one to two years. Studies name no firm upper limit, but…
What is young blood / plasma exchange, and does it actually work?
Plasma exchange clearly works in mice, but in humans there is still no evidence whatsoever of efficacy or safety. Do not be…
Preliminary evidence
Does hyperbaric oxygen therapy help against ageing?
HBOT shows interesting signals in small, early studies regarding telomere length and cerebral blood flow, but the evidence is…
Preliminary evidence
Does vitamin D help your immune system, or is that overrated?
Vitamin D genuinely helps your immune system, but the benefit of taking extra only really applies if you are deficient. If…
Moderate evidence
Does your immune system weaken as you get older?
Your immune system demonstrably weakens with age, but eating healthily and exercising can reduce the smouldering inflammation…
Yes · Strong evidence
Can you really lower your biological age, and does research support this?
There are promising hints that biological age is measurable and perhaps steerable, but this has not been proven. Wait for…
Preliminary evidence
How reliable are epigenetic clocks?
Epigenetic clocks are reliable predictors of health risks and the chance of dying sooner, but as an individual measurement…
Does hyaluronic acid on your skin really help against dryness and wrinkles?
Hyaluronic acid on your skin genuinely helps against dryness. Injections work best against wrinkles. A pill or powder adds…
Yes · Moderate evidence
Does a vitamin C serum help against pigmentation spots and ageing?
Vitamin C serums probably reduce pigmentation spots and early signs of ageing, but the studies are too small or lack control…
Yes · Moderate evidence
What is the best-proven remedy for wrinkles: retinol or vitamin C?
Tretinoin (prescription vitamin A) has the best evidence against sun-related wrinkles; a cream containing 5% vitamin C showed…
Strong evidence
Does testosterone decline in men with age?
Testosterone genuinely declines in men with age. Testosterone therapy is well supported only in men with established…
Yes · Strong evidence
Does clearing out senescent cells with senolytics help against ageing?
Senolytics show impressive results in animal studies, but in people the evidence is too thin for use outside a research…
Preliminary evidence
Is donating blood regularly good for your health?
Regular blood donation is safe for many people, but it can deplete your iron stores, especially if you menstruate or donate…
Moderate evidence
Do probiotic pills actually help your gut?
Probiotics genuinely help, but not for everything and not equally with every pill. The evidence is strongest for…
Yes · Moderate evidence
Does taking iron help, or is it actually a risk?
Taking iron clearly helps if you have a deficiency or anaemia, but is pointless and potentially risky if that is not the case.…
Moderate evidence
Does quercetin work against ageing and inflammation?
Quercetin shows promising signals in the laboratory and in animals, but in humans there is not yet solid evidence. Taking…
Preliminary evidence
What is NAD+ and what does it do in your body?
NAD+ is an indispensable molecule for energy, DNA repair and cell maintenance, and its levels measurably decline with age.…
Does CoQ10 help your heart or your energy levels?
For people with moderate to severe heart failure, CoQ10 has the most convincing evidence; for energy or sports performance in…
Yes · Moderate evidence
Does berberine help against high blood sugar (the natural metformin)?
Approach this with caution. Berberine measurably lowers blood sugar, but EFSA was unable to establish a safe intake level due…
Yes · Moderate evidence
Are sleeping pills harmful in the long term?
Long-term use of classic sleeping pills increases the risk of dependence, cognitive decline, and impaired driving ability.…
Yes · Moderate evidence
Do GLP-1 medications (such as Ozempic) help you age more healthily?
For people with cardiovascular disease, kidney disease, or fatty liver disease, GLP-1 medications offer proven benefits that…
Moderate evidence
Do multivitamins help with healthy ageing?
Daily multivitamins appear to offer some protection for the memory of older adults, but for most other aspects of healthy…
Moderate evidence
Do omega-3 (fish oil) supplements benefit my heart?
Fish oil reliably lowers triglycerides and can slightly reduce the risk of a heart attack in people with existing heart…
Moderate evidence
Does creatine also help ordinary people, not just athletes?
Creatine is not just for athletes. Combined with strength training, it helps older adults gain more muscle strength, and…
Yes · Moderate evidence
Does bowel cancer screening really help (fewer deaths)?
For people between 45 and 75 with an average risk, bowel cancer screening is worthwhile and widely recommended. It…
Yes · Strong evidence
Does metformin help you live longer in good health?
For people with diabetes, metformin has a reasonably well-supported health benefit, but as an anti-ageing agent for healthy…
Moderate evidence
Does rapamycin help people live longer in good health?
Rapamycin works in mice, but whether it also leads to a longer and healthier life in humans has not yet been demonstrated.…
Moderate evidence
Do you have enough vitamin D, and should you take a supplement?
For healthy adults under 75, the evidence for supplementation is weak, but for people aged 75 and older, those with…
Strong evidence
Is hormone therapy for the menopause safe and worthwhile?
Hormone therapy is worthwhile for menopausal symptoms and bone protection, but safety depends strongly on when you start,…
Yes · Strong evidence
Which vaccinations belong to healthy ageing?
For healthy ageing, the flu vaccine (high dose), the pneumococcal vaccine, the shingles vaccine, and the RSV vaccine are well…
Moderate evidence
Do collagen supplements work against skin ageing?
Studies show positive effects of collagen supplements on elasticity and wrinkles, although the funding behind the research…
Moderate evidence
Are NAD+ supplements (NMN/NR) worth it?
NMN and NR demonstrably raise NAD+ in your blood and appear to be safe, but whether you will notice any benefit in muscle…
Preliminary evidence
Does retinol help against wrinkles?
Retinol demonstrably works against wrinkles and improves skin texture, although tretinoin is more powerful for those who can…
Yes · Moderate evidence
Does sunscreen also protect against skin ageing?
Using broad-spectrum sunscreen daily demonstrably slows sun-induced skin ageing; anyone with concerns about chemical filters…
Yes · Moderate evidence
Is a full-body MRI scan worthwhile as a preventive measure?
For healthy people without elevated risk, the added value of a full-body MRI has not yet been proven: many detected…
Moderate evidence
What do peptides like BPC-157 do, and are they safe?
BPC-157 shows promising results in animal research for tissue healing, but has barely been studied in humans and its long-term…
Preliminary evidence
Do diabetes pills (SGLT2 inhibitors) also work against ageing?
For people with heart or kidney problems, large studies in people show clearly that these pills do considerably more than…
Moderate evidence
Does glucosamine help with joint complaints?
Glucosamine sulphate (1500 mg per day) may produce a modest reduction in pain from knee osteoarthritis after twelve months,…
Moderate evidence
Does ashwagandha really work against stress?
Ashwagandha demonstrably lowers the stress hormone cortisol, but whether it also makes you actually feel less stressed has not…
Moderate evidence
Is green tea really as healthy as they say?
Two to three cups of green tea a day fits well into a healthy lifestyle and is probably safe, but do not take concentrated…
Moderate evidence
Is it safe to take melatonin every night?
For healthy adults, melatonin is relatively safe with short-term use, but as a sleep aid for chronic insomnia it works…
Moderate evidence
Does taurine work against ageing?
Taurine supplements as a means of slowing ageing have not yet been proven in people. The results from animal studies are…
Preliminary evidence
Does taking resveratrol make sense as an anti-ageing strategy?
For humans there is no convincing evidence that resveratrol supplements do anything against ageing; the animal research is…
No · Preliminary evidence
Does spermidine actually do anything against ageing?
Spermidine has a well-supported mechanism of action and promising results in animal research, but evidence that a supplement…
Moderate evidence
Do DHEA or growth hormone help against ageing, or are they risky?
For healthy older adults without a hormonal disorder, DHEA offers little benefit and is not without risk. If you have a…
No · Preliminary evidence
Can you clear out "zombie cells" to slow down ageing?
The idea is biologically sound and produces impressive results in mice, but whether it works and is safe in people remains…
Moderate evidence
Is taking a daily aspirin smart or dangerous?
Whether a daily aspirin is smart or dangerous depends entirely on your age and medical profile. Take aspirin only on a…
Moderate evidence
Is a glucose meter useful if you don't have diabetes?
Without diabetes, a glucose monitor gives you some genuinely interesting information about how your body responds to food,…
Preliminary evidence
How healthy is meditation, and what does it actually do for you?
Meditation has a moderate but well-demonstrated effect on depression, anxiety and pain, and can safely be combined with other…
Strong evidence
Does cold water swimming improve healthy aging?
For most healthy people, occasional cold water swimming is probably safe. Do you have cardiovascular disease or high blood…
Preliminary evidence
Does regular sauna use help you live longer?
Regular sauna use is consistently linked to a lower risk of early death and heart problems in studies following large numbers…
Yes · Moderate evidence
Which supplements actually help with menopause?
Red clover isoflavones and black cohosh have the strongest evidence for reducing hot flashes; soy isoflavones also help to…
Moderate evidence
Does testosterone help after 50, and is it dangerous?
Testosterone can be worthwhile for men over 50 with a medically confirmed testosterone deficiency, but it is not a treatment…
Yes · Strong evidence
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An existing antimicrobial compound has an unexpected effect: it improves the energy factories inside immune cells. In worms,…
2 min
One anti-ageing therapy is never enough
Drugs that clear out aged cells work well in mice, but extend their lives less than calorie restriction does. Why? Because…
2 min
Stem cell therapies work via signals, not engraftment
Stem cell therapies are now widely available, but they work differently than originally assumed. Transplanted cells rarely…
2 min
Rapamycin works differently across tissues and ages
Rapamycin is the most studied drug candidate for slowing aging. But a single dose for everyone does not exist.
1 min
Longevity products need smarter regulation
The market for products claiming to slow aging is growing fast. But the rules for testing and approving them have not kept pace.
1 min
Aging biomarkers take center stage at Shanghai longevity forum
How do you measure whether an anti-aging treatment works without waiting decades for results? That was the central question at…
2 min
GLP-1 combo helps patients with diabetes lose 23% bodyweight
A combination of two weight-loss drugs led to a 23 percent reduction in body weight among people with obesity and type 2…
2 min
Brain peptide cuts tau damage in Alzheimer mouse models
A small protein is sharply depleted in the brains of Alzheimer’s patients. Replenishing it reduced tau build-up in mice,…
2 min
Grip strength tests gene therapy for aging
Your hand grip strength reveals more about your health than most people realize. Now it is being used to measure something…
2 min
Novo Nordisk bets on life beyond GLP-1 drugs
The company behind Ozempic and Wegovy is feeling the pressure. Investors want more than one successful product. And the CEO is…
2 min
Fasting improves symptoms in Huntington’s patients
Huntington’s disease has no effective treatment. Yet twenty patients showed measurable improvement after twelve weeks of…
2 min
Immune cells drive inflammatory bone marrow shift with age
As people age, bone marrow increasingly produces inflammation-promoting immune cells. This fuels chronic low-grade inflammation.
2 min
Ozempic drug extends healthy aging in older mice
Ozempic became famous as a weight-loss drug. Now a new study finds that the same medication extends lifespan in healthy older…
2 min
Platelet-rich plasma outlasts cortisone for spinal pain
Cortisone injections are a standard treatment for back pain caused by spinal narrowing. But a new study in dogs suggests that…
2 min
Lung drug makes blood look younger on six clocks
An experimental lung fibrosis drug did something unexpected: it made patients’ blood appear biologically younger. Researchers…
2 min
Chemo ages the liver faster than other organs
Platinum-based chemotherapy causes liver damage that goes beyond ordinary side effects. It accelerates the biological aging of…
1 min
Bones after menopause: 5 ways to prevent fractures
Bone loss after menopause can be slowed significantly. Here are the 5 best proven measures against fractures – and what wastes…
3 min
Blocking growth hormone extends mouse lifespan
Mice live measurably longer when their growth hormone stops working normally. That is established.
1 min
Aging clocks respond differently to the same treatment
Scientists want to know whether an intervention genuinely slows aging. But the measurement tools they use give different…
2 min
New drug cuts muscle loss in spinal muscle disease
A newly approved drug is the first to directly target the mechanism behind muscle wasting in spinal muscular atrophy. And the…
1 min
Europe wants longevity research out of the lab
The European Innovation Council has committed funding to biotechnology companies working on healthy aging. It is a signal that…
1 min
Childhood chemo leaves aging marks on the liver
Children who receive platinum-based chemotherapy may carry lasting DNA damage in their liver cells. A new study shows that the…
1 min
Blood test may detect cervical cancer recurrence earlier
After treatment for cervical cancer, the key question is whether the disease will return. A blood test based on freely…
1 min
Cialis linked to higher glaucoma risk in older men
A widely prescribed drug for prostate problems in older men may also raise pressure inside the eye.
1 min
Mass prescribing GLP-1 drugs has unintended consequences
GLP-1 medications are spreading fast. But when millions of people take them long-term, unexpected effects emerge that science…
1 min
Anti-inflammation drug fails to protect the aging heart
A promising strategy to fight cardiovascular disease by dampening inflammation appears to have faltered again.
1 min
A gene-edited pig kidney made way for a human one
Two patients first received a kidney from a genetically modified pig and then, months later, a human kidney. Both transplants…
1 min
First drug for a rare brain disease gets FDA approval
For people with Alexander disease, a rare and deadly neurological condition, a treatment now exists.
1 min
Psychedelics may protect ageing brain cells early
Psychedelics are already being studied as treatments for depression and anxiety. But new scientific commentary suggests…
1 min
GLP-1 drug extends lifespan in mice
GLP-1 drugs are known for weight loss. But new research shows they also extend lifespan in mice. That raises questions about…
1 min
Psilocybin shields nerves during chemotherapy
A common but poorly addressed side effect of chemotherapy is lasting nerve damage in the hands and feet.
1 min
GLP-1 drugs are reshaping employer health costs
GLP-1 drugs like Ozempic and Wegovy have become so widely used that employers in the US are being forced to rethink how they…
1 min
Heart drug fails: what the trial result tells us
A closely watched heart disease drug from AstraZeneca failed in a large phase 3 trial. The result also has implications for a…
2 min
Diabetes drug protects the heart via unexpected pathway
SGLT2 inhibitors, originally developed to lower blood sugar in diabetes, are known to protect the heart. But exactly how has…
1 min
Disrupted body clocks may drive age-related muscle loss
There are still no approved drugs for sarcopenia, the age-related loss of muscle mass and strength. A new analysis suggests a…
1 min
New cancer drug nearly doubles pancreatic cancer survival
Pancreatic cancer is one of the deadliest cancers. A new drug has nearly doubled median survival compared to standard…
1 min
7 ways to sleep better, and one that just costs you money
From consistent bedtimes to cognitive behavioural therapy: these are the seven best-supported ways to sleep better, and one…
3 min
Ozempic alternatives: what's out there and what actually works
From retatrutide to NMN, from metformin to electrolyte powders: a rundown of the best-known Ozempic alternatives and what the…
3 min
Bone drug extends life in fast-aging mice
A drug already used against bone loss turns out to also extend lifespan and improve muscle strength in mice with accelerated…
2 min
Metformin against aging: what the evidence now shows
Metformin has been the most widely prescribed diabetes drug for decades. Now there is growing interest in whether it can slow…
2 min
Retatrutide vs semaglutide: what sets the newest weight-loss drugs apart
Retatrutide vs semaglutide: what do we know about efficacy, side effects and muscle loss with the newest weight-loss drugs? A…
2 min
Cancer drug found to silence aging cells’ harmful signals
A class of drugs already used in breast cancer treatment may also act on a core mechanism of biological aging. Not by…
2 min
Cell-cycle protein drives inflammation in aged cells
Senescent cells keep the body in a state of chronic inflammation. New research shows that a protein normally involved in cell…
1 min
Collagen, skin cycling, Vaseline: what the science actually says about skin care right now
Which skin care trends are backed by evidence and which are not? A rundown of what science learned this year about collagen,…
3 min
Mitochondria produce their own immune weapon
Mitochondria do more than generate energy. They also produce a peptide that directly attacks bacteria and reprograms immune…
2 min
Ozempic and other interventions: what the evidence actually supports
Ozempic has solid evidence behind it for heart, kidney and liver disease. But what about rapamycin, metformin and…
3 min
Non-opioid pain drugs still fall short for aging patients
Pain is one of the most disabling problems in aging. Opioid painkillers work well, but carry serious risks. The search for…
2 min
AI model simulates a human cell from DNA to behavior
Simulating a cell on a computer has been a goal of biologists and computer scientists for decades.
1 min
Stem cell therapy shows promise but lacks consistency
Stem cell therapies are offered globally, including in clinics with little regulatory oversight. They can temporarily reduce…
2 min
Estrogen use linked to lower Alzheimer’s risk
Women who used estrogen-only hormone therapy later in life were 39 percent less likely to be diagnosed with dementia. They…
2 min
Bryan Johnson's biohacks put to the test
Bryan Johnson's biohacks examined: which interventions have serious evidence behind them, which have been debunked, and where…
3 min
New blood cancer pill opens a drug class
A new oral treatment for an aggressive blood cancer has been approved by US regulators.
1 min
GLP-1 drug retatrutide fuels a growing black market
Retatrutide has not yet been officially approved, but a large illegal market for it already exists. Eli Lilly is now moving to…
1 min
Cell pH sensor mapped at atomic level for first time
The body carefully regulates the acidity inside and around cells.
2 min
One drug combination clears senescent and cancer cells
Senescent cells and cancer cells seem like opposites. But they share a key survival trick. A new drug combination exploits…
1 min
Blood stem cells can be rejuvenated several ways
The immune system weakens as blood stem cells in the bone marrow age.
2 min
Complexity makes aging harder to slow down
In a worm, a single genetic tweak can double lifespan. In a mouse, that is far from possible. In humans, it seems even harder.
1 min
Targeted light therapy clears gum bacteria linked to aging
Gum disease is not just a dental problem. Research suggests the bacterium driving gum inflammation also fuels age-related…
2 min
Thyroid slowdown may be a built-in survival response
Sometimes the thyroid produces less of its key hormone even when the gland itself is perfectly healthy. New research suggests…
2 min
A DNA reading-frame detail decides Rett syndrome severity
Not every mutation in the same gene leads to the same disease.
1 min
Translating animal studies to humans is harder to measure than assumed
Promising animal results that fail in humans: it is one of the biggest frustrations in biomedical science. But how do you…
2 min
A cell-surface sugar guides coronavirus entry
ACE2 has long been considered the gateway through which SARS-CoV-2 enters cells.
1 min
Five longevity drugs share one metabolic signature
Five different treatments that extend mouse lifespan all raise the same molecule in blood and brain.
2 min
Dangerous fungus hides in hair follicles to evade immunity
A drug-resistant fungus that increasingly infects hospital patients has found a clever hiding place: the hair follicle. There…
2 min
Longevity medicine is moving into mainstream care
Doctors today rarely focus on slowing aging itself. That is about to change. A growing number of countries are reconsidering…
1 min
Exosome therapy limits heart scarring after attack
After a heart attack, the heart heals poorly. Damaged tissue forms scar tissue, permanently weakening its pumping function.
1 min
A brain circuit grows stronger during opioid abstinence
Why do people relapse after weeks or months without drugs? New research in rats identifies a specific brain connection that…
1 min
A three-drug mix clears aging cells at lower doses
The accumulation of senescent cells in tissues is one of the recognised drivers of aging. A new three-drug combination appears…
1 min
The peptide craze is outpacing the science
Injectable peptides have become the new supplement. But most of the ones being sold have never been tested in humans, and some…
1 min
Muscle protein brakes growth via mTOR pathway
Muscles do not just grow through exercise. There is a built-in brake on muscle growth, and researchers have now clarified how…
1 min
Cancer drugs grown sustainably in yeast
Two widely used cancer medicines are difficult to produce and depend on a rare plant species. Researchers have now found a way…
1 min
Parkinson’s drug reshapes cell architecture unexpectedly
A much-discussed Parkinson’s inhibitor does something unexpected: depending on how the molecule approaches its target, it…
2 min
Liver drug’s mechanism finally revealed
One of China’s most widely used liver treatments has been clinically approved for decades, but its mechanism was never understood.
1 min
New Alzheimer’s drug shows low brain-bleed risk in trial
Existing drugs that clear amyloid from the brain can cause small brain bleeds or brain swelling in some patients.
1 min
Woman dies after NAD⁺ infusion at wellness clinic
A 27-year-old woman in New York City died after receiving an intravenous infusion at a local wellness clinic. The treatment…
2 min
Brain peptide shapes learning and memory in the hippocampus
A neuropeptide long known as a digestive hormone turns out to play a key role in spatial learning and memory. Switching it off…
1 min
FDA panel greenlights five peptides for compounding pharmacies
Five peptides are on the verge of becoming available through regulated pharmacies in the United States.
1 min
Mini brains predict who benefits from Alzheimer’s treatment
Not every Alzheimer’s patient responds to treatment the same way. That has long been known, but there was no reliable method…
1 min
How to steer your hormones after 40
Hormones help drive ageing, but you are not entirely at their mercy. Here is what the evidence really says about lifestyle…
3 min
A small molecule reactivates the aging thymus in mice
The thymus is a small organ that produces T-cells for the immune system. By your fifties, almost no active thymus tissue remains.
2 min
Merck’s HIV prevention pill reaches poorest countries first
A new once-a-month pill that may prevent HIV infection does not have to wait for wealthy countries first.
1 min
Tau-targeting drugs gain fresh momentum in Alzheimer’s
For years, Alzheimer’s research focused on amyloid, a protein that clumps in the brain.
1 min
FDA panel backs legal access to four longevity peptides
Four substances popular in the longevity world but not officially approved may soon be available through compounding…
1 min
Engineered enzyme reverses protein damage linked to aging
Proteins that persist in the body for decades slowly accumulate sugar-linked damage. This damage has long been considered…
2 min
The longevity industry is maturing, slowly and messily
The longevity industry has existed as a recognisable field for over a decade. The first wave of hype has passed. What remains,…
2 min
Ozempic slows biological ageing markers in people with HIV
Semaglutide, the active ingredient in Ozempic and Wegovy, appears to slow biological ageing markers in adults with HIV. This…
1 min
Drug for spinal injury repairs DNA in Alzheimer brains
A drug originally developed for spinal cord injury appears to do something no approved Alzheimer’s treatment has managed:…
1 min
Targeting senescent cells cuts post-chemo inflammation
Chemotherapy saves lives but accelerates biological ageing in the body.
1 min
A receptor in the thymus slows immune aging
As we age, the thymus, the organ that trains immune cells, shrinks and fills with fat. That weakens immunity.
1 min
Diet barely changes the burden of aging cells
Calorie restriction, omega-3 fats, metformin: nutrition is often pitched as a brake on aging. But does it actually work at the…
2 min
Free AI tool checks longevity supplements for evidence
A free, searchable database of more than 600 longevity interventions is now open to both humans and AI systems.
1 min
Weight-loss startup bets against GLP-1 drugs
The obesity drug market is dominated by one type of medicine.
1 min
Clearing aged cells may boost stem cell therapies
Stem cell therapies often underperform in clinical trials. A new mouse study suggests that the hostile environment of aging…
2 min
US agency funds custom gene editing for rare diseases
Hundreds of rare diseases have no treatment. A US government programme is now investing 160 million dollars in seven teams…
2 min
Molecular glue reaches cancer targets once out of range
Most drugs work by blocking a single protein. But a special class of molecules, called molecular glues, works differently.
2 min
A network map of aging finds drug candidates
Aging is not a single process but an interconnected web of molecular changes.
2 min
One gene marker predicts childhood cancer survival
In childhood cancer, predicting who responds well to treatment and who does not is critical.
1 min
AI cell model spans 1.5 billion years of aging biology
One model that understands the biology of virtually every cell on Earth. That sounds far-fetched, but researchers have built…
1 min
Brain’s tiny vessels may be causing common strokes
Doctors have treated a common type of stroke with blood thinners and clot-busting drugs for decades. But new research suggests…
1 min
Brain cells deep in the skull steer reward decisions
A small brain region targeted in Parkinson’s treatment also plays a key role in how decisions are shaped by reward.
1 min
Self-experimenting with aging: bold move or bad idea?
More people are testing drugs, peptides, and supplements on themselves in pursuit of a longer healthspan.
1 min
Aging treatments: knowledge is the real barrier
Most debate about longevity treatments focuses on who can afford them. But a recent analysis argues the real obstacle is not…
1 min
Late-life gene therapy extends mouse lifespan by 20 percent
A single injection of a gene therapy targeting muscle tissue extended the median lifespan of male mice by twenty percent.…
1 min
Small molecule slows nerve damage in ALS mice
ALS kills nerve cells fast, and no treatment stops the process.
1 min
Gene therapy for aging: why progress is so slow
Dozens of genes are known to influence ageing. Yet gene therapies targeting them remain nearly absent from clinical practice.…
2 min
Synthetic cell divides and copies its own DNA
Scientists have built an artificial cell that can divide and copy its DNA. Whether it counts as truly alive is debated, but…
1 min
Alzheimer drug targeting tau clears first phase-2 hurdle
An experimental Alzheimer’s drug targeting the protein tau has shown promising early results. Detailed data will be presented…
2 min
Network medicine maps old drugs to aging pathways
Could a blood pressure pill you already take also slow your ageing? Researchers at Northeastern University and Harvard…
1 min
Stem cell therapy edges closer to real rejuvenation
Stem cells are considered one of the great promises of anti-aging medicine. But how realistic is that promise?
2 min
New target cuts clot risk without bleeding danger
Blood clotting is normal and necessary after an injury. But with aging, the system misfires more often, producing dangerous clots.
2 min
AI scientist speeds up the search for new drugs
Artificial intelligence that can reason independently like a scientist. Pharmaceutical companies offered tens of millions to…
2 min
CRISPR edits embryos more precisely than before
Genetic editing of human embryos is entering a new phase. A more precise version of CRISPR causes less damage than earlier tools.
1 min
Anti-aging trials need a better measuring stick
How do you measure whether an anti-aging treatment truly works in people? That is one of the hardest problems in the longevity…
1 min
Are GLP-1 drugs actually slowing down aging?
GLP-1 receptor agonists are widely used for obesity and diabetes. But could they do something more fundamental, actually…
1 min
Old drugs, new tricks: targeting the aging network
What if drugs already approved for other diseases could also slow aging?
2 min
Blocking one protein helps injured kidneys heal
A drug originally developed to help the heart recover after a heart attack may also help kidneys repair themselves after injury.
2 min
Eye disease startup raises $330 million for ageing trial
A startup targeting eye diseases that predominantly affect older people has raised $330 million.
1 min
GLP-1 drugs are reshaping health spending
Weight-loss drugs like semaglutide are wildly popular. But the bill is mounting fast: the US spent nearly $5.
1 min
Alzheimer’s risk gene points to new drug target
The biggest genetic risk factor for Alzheimer’s disease sits in a single gene: APOE4.
1 min
Blood enzyme accelerates bone aging in mice
A protein that accumulates in the bloodstream as we age directly damages bone tissue. Researchers found a way to selectively…
2 min
Gene therapy keeps aging organs healthier in mice
What if a single injection could keep your organs healthier into old age? In mice, that principle now works in practice.
2 min
Copper compound clears Alzheimer’s brain proteins
A copper-based compound restored the brain’s ability to clear toxic proteins linked to Alzheimer’s disease in laboratory…
2 min
Clearing aged cells first boosts stem cell therapy in mice
Clearing out worn-out cells before a stem cell treatment produces better outcomes. That is what a mouse study found when…
2 min
A longevity drug that mimics exercise effects
Exercise is good for you. Everyone knows that. But what if a pill could replicate its biological effects? That is exactly what…
2 min
GLP-1 drugs: who wins the market race?
Wegovy and Zepbound currently dominate the weight loss drug market. But Pfizer, Amgen and others are positioning themselves to…
1 min
An antidepressant extends lifespan in aging mice
A long-established antidepressant gave aging mice not just a longer life, but a healthier one. The mechanism behind it is…
2 min
Senolytics reshape immunity and metabolism in aged mice
What happens inside the body after senescent cells are cleared? A new study maps the answer in unprecedented detail, and the…
2 min
Biology’s speed limits can be broken
Evolution has capped the speed of biological processes for billions of years.
1 min
GLP-1 drug measurably slows biological aging
A widely used weight-loss drug does more than shed pounds. Researchers found that semaglutide also slows biological aging, as…
2 min
First patient receives cell-rejuvenation therapy for the optic nerve
Life Biosciences has become the first in the world to dose a patient with a gene therapy that rejuvenates aging cells in the…
2 min
Mapping TYK2 reveals new paths for immune therapy
A protein long studied in autoimmune disease turns out to offer more drug targets than previously thought. And some people are…
2 min
New brain cell target slows Alzheimer’s damage
Researchers identified a new mechanism that damages nerve cells in Alzheimer’s disease. They also created an experimental…
1 min
Two strategies dominate the longevity field
How do you treat ageing? A new review in Signal Transduction and Targeted Therapy maps the landscape into two broad camps:…
2 min
GLP-1 drugs cost supermarkets a billion
People using GLP-1 drugs for weight loss eat measurably less. In the United Kingdom, that already wiped nearly a billion…
1 min
Blocking PAI-1 may slow down aging
A small group of people with a rare inherited mutation live on average seven years longer than others. They lack a working…
2 min
A KRAS drug nearly doubles pancreatic cancer survival
Pancreatic cancer is one of the deadliest cancers. Average survival after diagnosis is measured in months, not years. A new…
1 min
One aging clock works in mice and humans
Most tests that measure how fast you age only work in humans. So how do you know whether an anti-aging treatment that works in…
1 min
Nanomaterials could finally fix damaged cartilage
Osteoarthritis affects hundreds of millions of people worldwide and ranks among the most underestimated consequences of aging.…
1 min
Gene therapy cuts brain damage in two diseases
A protein involved in cellular transport turns out to limit serious brain damage in mice. And it works across two distinct…
2 min
Algorithm predicts how cells respond to interventions
What happens inside a cell when you switch off a gene or add a compound? Until now, you had to run the experiment to find out.
2 min
Thalion wants hundreds of millions for aging biology
Venture capital chases clinical results. Government funding is shrinking. A new non-profit called the Thalion Initiative is…
1 min
NewLimit raises $435 million for liver therapy
A startup aiming to reverse aging has raised nearly half a billion dollars.
2 min
BPC-157 is popular with biohackers, but the science is thin
A peptide beloved in biohacking communities has fifty years of research behind it. Almost all of it comes from one scientist…
2 min
BRCA mutations reshape the immune landscape of lung tumours
People with certain cancer-linked gene mutations sometimes respond better to immunotherapy. New research explains why: faults…
2 min
AI model designs RNA splicing from scratch
A new AI model can predict how RNA is spliced in different tissues, and can also design new RNA sequences that produce a…
1 min
Stress protein Hsp70 monitors DNA damage in cells
A protein best known for helping other proteins fold correctly turns out to play an unexpected role in the cellular response…
2 min
Hepatitis B ‘functionally cured’ in nearly one in five
Chronic hepatitis B infects 250 to 300 million people worldwide and kills one million every year. The standard treatment cures…
2 min
Gene Therapy for Older Patients via Medical Tourism
A new foundation is offering older patients gene therapy outside of regular clinical channels. The treatments have not been…
2 min
Cyclarity reports safety data for atherosclerosis drug
A toxic form of cholesterol accumulates in blood vessels and contributes to atherosclerosis.
1 min
AI finds hidden GLP-1 side effects in Reddit
Clinical trials systematically miss side effects that patients themselves notice.
1 min
Summit reveals tensions in longevity investment
Who is paying for longevity science, and what do they expect in return? At the STAT Breakthrough Summit West, leaders from…
1 min
Retro Biosciences reaches 1.8 billion valuation
A longevity startup aiming to add ten healthy years to human lifespan has been valued at 1.8 billion dollars.
1 min
Reducing amyloid buildup: new enzyme target could revolutionize Alzheimer’s treatment
An enzyme that received little scientific attention turns out to play a major role in amyloid accumulation in the brain.
1 min
LRRK2 inhibitor fails in Parkinson trial
A closely watched experimental Parkinson’s treatment has failed its first major clinical test.
2 min
Tumors Destroyed by a Smart mRNA T-Cell Therapy
Cancer immunotherapy only works for a minority of patients. The reason: many tumors leave the immune system cold. A new mRNA…
1 min
Nucleoside synthesis gets a powerful new platform
Many antiviral and cancer drugs are built on nucleosides: small molecules that resemble the building blocks of DNA and RNA.
1 min
Cyclarity clears phase 1 trial for 7KC drug
Most treatments for cardiovascular disease work by lowering cholesterol or dampening inflammation. Cyclarity is taking a…
1 min
mRNA therapy sharply raises immune response to cancer
Most cancer immunotherapies work only for a minority of patients. A new mRNA treatment drastically increased immune responses…
2 min
Alzheimer drug trials grow but cures remain elusive
The number of clinical trials testing Alzheimer’s drugs is rising steadily. Yet approved treatments remain few. Researchers…
2 min
Repair Bio targets free cholesterol in liver
Cardiovascular disease is the leading cause of death worldwide. Most treatments slow its progression. Repair Biotechnologies…
2 min
Living implant delivers drugs using contained bacteria
An implant that monitors when to release medication and produces that medication itself. Researchers have achieved this using…
2 min
Metformin targets ATP synthase in cancer cells
Metformin has been the most prescribed type 2 diabetes drug for decades. New research now shows it also inhibits cancer cells…
2 min
Nanoparticles reverse Alzheimer’s symptoms in aged mice
Old mice with Alzheimer’s features behaved like healthy young animals after a nanoparticle treatment. The therapy addresses…
2 min
Mixed pathologies complicate dementia research
Most people with dementia do not have one disease. They have two or three simultaneously. That makes treatment research far…
2 min
GLP-1 drugs cause no extra muscle loss
Critics have warned that GLP-1 drugs strip away more muscle than ordinary dieting. A new study puts that concern in perspective.
2 min
Toxic cholesterol cleared via urine in trial
Most cardiovascular therapies lower cholesterol or reduce inflammation. A new clinical result takes a different approach:…
2 min
New therapy targets toxic cholesterol byproduct in arteries
Most cardiovascular treatments lower LDL cholesterol or reduce inflammation. A new drug candidate takes a different approach,…
2 min
Open-source AI reviews longevity interventions systematically
Anyone researching longevity supplements runs into the same wall: vast literature, uneven quality, contradictory conclusions.…
2 min
Light therapy may repair the nerve-muscle connections that quietly break down as we age
Muscle loss in older age isn’t just about inactivity or poor diet.
2 min
Scientists Upgraded CRISPR Using Only Computers, and It Actually Works
Researchers have designed an improved version of the CRISPR gene-editing tool that can reach more locations in the genome, and…
2 min
An AI That ‘Thinks’ Beats Doctors on Messy Real-World Cases, Here’s What That Actually Means
A new breed of AI system that reasons step by step has outperformed experienced physicians on complex clinical cases drawn…
2 min
A new way to redesign drug molecules, one nitrogen atom at a time
Most drug development failures happen not because the biological idea was wrong, but because the molecule had the wrong…
2 min
AI can reason like a doctor, but that’s only the beginning of the problem
Artificial intelligence now scores at the top of medical reasoning tests. The harder question is what that actually means for…
2 min
Chemists are inserting nitrogen where it was never possible before; and it could transform drug discovery
Drug development often starts with chemistry that looks abstract at first glance. But a new technique for building nitrogen…
2 min
Blocking two proteins reduced lung scarring in animals, a new lead for a disease with almost no good treatments
Lung fibrosis replaces healthy tissue with scar tissue, makes breathing progressively harder, and has almost no treatments…
2 min
Seizures on demand: a smarter way to test epilepsy drugs
Drug development for epilepsy has always faced a frustrating bottleneck: waiting for a seizure to happen.
2 min
A reasoning AI outperformed real doctors on messy, real-world patient data
A new type of AI that reasons step by step, rather than just pattern-matching, beat experienced physicians on complex…
2 min
A popular anti-aging drug combination causes brain damage in mice
Millions of people are already experimenting with senolytic treatments to slow aging.
2 min
April 2026 in longevity science: what moved the field forward
From new data on senolytic therapies to AI-designed anti-aging molecules, April 2026 was a busy month for the science of…
2 min
Scientists built working proteins with one fewer building block, using AI
Life on Earth uses twenty amino acids to build every protein in every living thing. Researchers wondered whether all twenty…
2 min
A company claims their supplement mix outlives rapamycin in mice, here’s why that needs scrutiny
A new study funded by longevity company Seragon reports that their combination treatment extends the lives of old mice more…
2 min
A Popular Anti-Aging Treatment Damages Brain Cells in Mice
Dasatinib and quercetin, the most widely used senolytic combination in longevity circles, causes damage to specific brain…
2 min
The rejuvenation field is growing fast, but how close is it to delivering?
Conferences are filling up, startups are raising money, and the first human trials of treatments aimed at reversing biological…
2 min
The drugs clearing Alzheimer’s brain plaques aren’t helping patients, and that’s a problem
The most advanced Alzheimer’s treatments ever developed can now demonstrably remove the protein clumps long blamed for the…
2 min
Two old cancer drugs outperform a newer rival at clearing the body’s worn-out cells
In a mouse model of spinal disc degeneration, a cheap, decades-old drug combination beat a newer and more expensive competitor.
2 min
Longevity companies are finding workarounds to get their first human data
The cost of testing an experimental treatment in humans has grown so high that many promising longevity interventions never…
2 min
A new anti-inflammation drug clears its first human safety test
A small molecule that blocks one of the body’s central inflammation engines has passed its first clinical test in humans.
1 min
Rapamycin may blunt the benefits of exercise in older people
Rapamycin is widely considered the leading drug candidate for slowing aging, but a new study suggests it may undercut the…
2 min
Alternative routes to human data: longevity companies search for a way around the regulatory deadlock
The cost of testing an experimental treatment in humans has risen so steeply that many promising longevity interventions never…
2 min
A new anti-inflammation drug clears its first human trial
A small molecule that blocks one of the body's central engines of inflammation has passed its first clinical test in humans.
2 min
Programmable protein factories inside living cells
What if the body’s own cells could be reprogrammed as tiny factories, producing exactly the protein a patient needs at the…
1 min
The body’s own anti-inflammatory fades with age, and injecting it back seems to help
As people age, their risk of joint inflammation rises, not just because joints wear down, but because the body quietly loses…
2 min
A molecular loop drives kidney disease progression. Scientists can now see how it works
Chronic kidney disease affects roughly one in ten adults worldwide, yet the molecular reasons why some patients deteriorate…
2 min
Scientists image the molecular pump that lets bacteria shrug off antibiotics
Antibiotic resistance is one of medicine’s most pressing threats, and one of bacteria’s cleverest tricks is simply pumping…
2 min
An old cancer drug can kill the zombie cells linked to aging
A drug used for decades to treat a rare blood cancer turns out to also clear senescent cells, the so-called zombie cells…
1 min
Scientists Turned Blood Stem Cells Into Lifelong Protein Factories
A one-time treatment that makes your body produce its own medicines, for life.
2 min
A forgotten brain signal reduces Alzheimer’s plaques and inflammation in mice
After decades of research focused on amyloid plaques and tau tangles, a study points to a neglected signalling molecule in the…
2 min
CAR therapy for Alzheimer’s: reprogramming brain cells to fight the disease from within
The same technique that has transformed cancer treatment, reprogramming immune cells to hunt down disease, is now being aimed…
2 min
Most longevity treatments were tested on one sex, and that’s a serious problem
Women live longer than men, but spend more years in poor health. Many anti-ageing interventions work better in one sex than…
2 min
Why men and women age differently, and why anti-aging therapies are ignoring that gap
Most anti-aging interventions that work in mice work better in females than males, or the other way around. Yet the vast…
2 min
The first trial to reprogram human cells younger: is the FDA finally treating aging as a disease?
Life Biosciences is about to become the first company to test a therapy that makes cells biologically younger, not as a…
2 min
A long-overlooked brain protein slows Alzheimer’s in mice, and drugs targeting it already exist
Instead of targeting amyloid or tau, the usual suspects in Alzheimer’s research, scientists focused on a neuropeptide that had…
2 min
A gene therapy is teaching the heart to repair itself after a heart attack
When a heart attack strikes, heart muscle dies, and it doesn’t grow back.
2 min
The FDA just opened the door to biological rejuvenation
The FDA doesn’t officially recognise aging as a disease. Yet this year, for the first time, a therapy designed to make cells…
2 min
NAD+ combination treatment restores muscle and bone in old mice
Topping up a single supplement helps a little. But what if you also stopped the leaking?
2 min
NAD+ combination treatment restores muscle and bone in old mice
Topping up one supplement helps a little. But what if you also plug the leak at the same time? Researchers put that…
2 min
Turning back the clock on cells, the FDA says yes
The US drug regulator does not officially recognise ageing as a disease. Yet this year, for the first time, a therapy designed…
2 min
Artificial intelligence has fundamentally changed how scientists design proteins
Proteins are the machines of life, and designing new ones from scratch used to take years of painstaking work. AI has upended…
2 min
The first therapy designed to make human cells biologically younger is entering clinical trials
For the first time, a treatment that resets the biological age of cells is moving into human trials.
1 min
A drug that clears ‘zombie cells’ has been tested in humans for the first time
Ageing cells that refuse to die accumulate in our bodies and cause widespread damage. A new drug can now selectively eliminate…
2 min
A cancer therapy that targets aging cells could finally crack solid tumors
CAR T-cell therapy transformed blood cancer treatment. But for solid tumors, the most common cancers, it has largely failed.
2 min
Rapamycin as an anti-aging drug: real human trials are finally coming
Thousands of people already take rapamycin, a transplant drug, hoping it will slow their aging. For years, the evidence behind…
2 min
An AI company just closed a $2.75 billion deal for drugs it designed itself
Insilico Medicine uses artificial intelligence to design new drugs.
2 min
How a More Powerful CAR T-Cell Therapy Could Finally Take On Solid Tumors
CAR T-cell therapy has saved lives in blood cancers. But in solid tumors, the most common forms of cancer, it has barely made…
2 min
Rapamycin as an anti-aging drug: real human studies are finally here
For years, thousands of people have been taking rapamycin — a drug originally designed to prevent organ rejection after…
2 min
A $2.75 billion AI drug deal, and what it signals for the future of medicine
Insilico Medicine, a company that uses artificial intelligence to discover new drugs, has signed a deal worth up to $2.75…
2 min
Longevity science: what did March 2026 bring?
From a database that supports thousands of aging researchers yet faces extinction, to promising experiments with plasma…
2 min
Turning Tumors Against Themselves: A New Approach to Cancer Treatment
Cancer treatment has traditionally meant attacking from the outside: chemotherapy, radiation, surgery. An emerging strategy…
1 min
Scientists built an almost indestructible protein using AI, and it could reshape drug design
Proteins are fragile. Heat, acid, mechanical stress, they deform and fall apart.
2 min
A drug that clears out aging skin cells passes its first human safety test
A biotech company targeting so-called zombie cells, cells that stop dividing but refuse to die and instead damage surrounding…
2 min
An AI tool designed a protein that's nearly impossible to break
Proteins are fragile structures. Heat, acid, mechanical stress: they warp or fall apart. But what if you could build a protein…
2 min
A drug that clears out aged skin cells passes its first human safety test
A company focused on eliminating "zombie cells", cells that stop dividing but refuse to die and instead cause damage…
2 min
Attacking Atherosclerosis from Within: Immunotherapy Takes Aim at the Most Dangerous Cells in Artery Walls
Arterial plaque is the silent engine behind most heart attacks and strokes.
2 min
Stem Cell Therapy for Age-Related Frailty: Promising Early Signals, Many Open Questions
Frailty in older adults, the combination of muscle loss, fatigue, and heightened vulnerability, has no effective treatment.
1 min
Stem Cell Therapy for Age-Related Frailty: Cautious Optimism as New Data Emerge
Frailty in older adults: the combination of muscle loss, fatigue and heightened vulnerability, still has no effective treatment.
2 min
Immune cells that can sniff out tumors: a new chapter in cancer therapy
Cancer cells leak specific metabolites, chemical byproducts of their abnormally high energy use. Researchers have now…
2 min
Brain health and aging take center stage at a new conference: what do we actually know about neural decline?
As longevity research races ahead, one organ keeps getting left behind when it comes to treatment options: the brain.
1 min
BioAge Labs: Promising Early Data for a New Metabolism Drug Targeting Aging
A small biotech company that treats aging as the biological root of metabolic disease has released early clinical results for…
2 min
Rubedo's skin treatment targets senescent cells: early clinical results look promising
An AI-driven biotech company reports the first clinical results for a treatment that selectively targets senescent cells, not…
2 min
After a Clinical Setback, BioAge Labs Shows Early Promise With a New Drug Candidate
BioAge Labs lost its lead drug candidate last year after a phase 2 trial failure.
1 min
Two Natural Fatty Acids Can Kill Senescent Cells, Here’s What That Means
Senolytics, drugs that selectively eliminate aged, dysfunctional cells, are among the most closely watched interventions in…
2 min
Building CAR T Cells Inside the Body: A New Frontier in Cancer Therapy
CAR T-cell therapy is one of the most powerful tools oncology has produced in decades, but its complexity and cost put it out…
2 min
BioAge Labs pushes forward after setback: new drug candidate shows promising early data
BioAge Labs lost its most advanced drug candidate last year after a clinical trial failure.
1 min
Pollution-triggered asthma: how pain sensors in the lungs derail the immune response
Asthma caused by air pollution responds differently to treatment than classic allergic asthma, and now we know why.
2 min
Experts on senolytics: 'The science is mature enough to take seriously, but nowhere near ready for widespread use'
Cellular senescence has grown into one of the central themes in longevity science. But how far has the field actually come?
2 min
Rubedo's skin treatment clears its first clinical hurdle: targeting senescent cells selectively in living tissue
The first clinical evidence that senolytics can work selectively in human tissue is here, and it comes not in a pill but in a…
2 min
Red blood cells as taxis for healthy mitochondria: Parkinson's treated in mice
Mitochondria, the powerhouses of the cell, have been a promising but stubbornly hard-to-reach therapeutic target for decades.
2 min
A skin-based anti-aging drug just scored its first clinical win. Here's what that means.
A biotech company focused on destroying aging cells reports positive results from a phase 1 study of a skin treatment.
2 min
Rubedo's senolytic works in humans: first clinical evidence for targeted cellular rejuvenation
For the first time, a senolytic drug that specifically targets aged cells has shown positive results in a randomized,…
1 min
The morning sickness hormone that curbs the urge to drink, could it treat addiction?
GDF15, the hormone behind morning sickness in pregnant women, also appears to reduce the craving for alcohol.
1 min
New fatty acids kill senescent cells while leaving healthy ones unharmed
Senolytics are compounds that clear out aged cells without damaging healthy ones. Until now, the options have been limited.
2 min
Building CAR T cells inside the body: cancer research takes a new turn
CAR T-cell therapy is one of the most promising weapons against cancer, but producing it is slow, expensive and fiendishly…
2 min
Pain Sensors in the Lungs Are Making Pollution-Driven Asthma Worse
Pollution-exacerbated asthma is notoriously resistant to standard treatments.
2 min
Rubedo’s Senolytic Compound Clears Phase 1, and the Implications Go Beyond Skin
A biotech company targeting senescent cells has reported positive preliminary results from its first human trial.
2 min
Two natural fatty acids turn out to be senolytics: they clear out aging cells
A new study has identified two polyunsaturated fatty acids that effectively eliminate senescent cells, the so-called "zombie…
2 min
What Senescence Experts Actually Think About Senolytics Right Now
Cellular senescence has become one of the most active frontiers in longevity science.
2 min
BioAge Labs scores a breakthrough with new metabolism drug targeting aging
BioAge Labs, a biopharmaceutical company focused on slowing biological aging, has presented positive interim results for its…
1 min
A Fatty Acid Found in Plant Oils Can Kill Senescent Cells, Here’s What That Means
The hunt for safe senolytics, drugs that selectively eliminate aged, dysfunctional cells, has largely focused on repurposed…
2 min
Two Natural Fatty Acids Can Kill Senescent Cells, Here’s What That Means
Senolytics, drugs that selectively eliminate aged, dysfunctional cells, are among the most closely watched interventions in…
2 min
After a Clinical Setback, BioAge Labs Shows Early Promise With a New Drug Candidate
BioAge Labs lost its lead drug candidate last year after a phase 2 trial failure.
1 min
Building CAR T Cells Inside the Body: A New Frontier in Cancer Therapy
CAR T-cell therapy is one of the most powerful tools oncology has produced in decades, but its complexity and cost put it out…
2 min
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