Nutrition & prevention

Why does female fertility decline so much faster than the rest of the body ages?

Scientists have found a way to limit brain damage in Alzheimer’s disease without removing the well-known tau protein. In mice,…

What if there isn’t one ideal diet, but ten? New research suggests that multiple healthy eating patterns are associated with…

The lining of blood vessels consists of cells that age particularly fast. When these cells become senescent, they secrete…

Eat as much as you want, but keep it plant-based and low-fat. For people with type 2 diabetes, this approach produced better…

During the menopausal transition, sixteen proteins in the blood shift in ways that are linked to brain health later in life.

Stem cells meant to repair gum tissue sometimes age so rapidly in the lab that they stop working.

The heart has almost no ability to repair itself after damage. New research in mice identifies a protein that appears to…

For years, researchers thought restricting methionine extended the lives of lab animals. New animal research suggests that…

There is a protein in your cells that constantly monitors energy levels. Activate it directly, and lab animals live longer.…

Brain degeneration linked to tau proteins may be triggered from outside the brain itself.

What damages your immune system after 40? From chronic stress and heavy drinking to nutritional deficiencies and air…

The protein p53 is best known for suppressing tumors. But what happens when it is lost in healthy tissue?

Could what you eat protect your brain from shrinking? A new study suggests that people who closely follow the MIND diet show…

Drugs that clear out aged cells work well in mice, but extend their lives less than calorie restriction does. Why? Because…

Fat tissue contains cells that can produce heat instead of storing energy. A newly identified protein turns that switch on,…

The body has an internal clock that governs almost every cell.

A small protein is sharply depleted in the brains of Alzheimer’s patients. Replenishing it reduced tau build-up in mice,…

Some people carry variants of DNA repair proteins that impair how those proteins function.

In Alzheimer’s disease, the tau protein accumulates in neurons in an abnormal form.

Omega-3, stair climbing, gum health, HRV and your resting heart rate: what does the evidence actually say? Here is how the…

Women who struggle to conceive sometimes have egg cells that never mature properly.

A rare childhood brain disorder has uncovered an unexpected mechanism: the way proteins are chemically decorated with sugar…

Chronic gut inflammation affects millions of people and is closely linked to accelerated aging.

Kefir and yoghurt have real backing for your gut microbiome. But kombucha and kimchi? The evidence in humans is not yet there.…

When tissue is damaged, some cells accelerate repair in a way nobody expected. They merge into large multi-nucleated giants.…

Huntington’s disease has no effective treatment. Yet twenty patients showed measurable improvement after twelve weeks of…

What you eat and how you live has a measurable effect on DNA protection. Find out which choices actually work – and where…

A protein in the brain declines with age. In mice, lower levels are linked to more inflammation, weaker bones, thinner skin,…

After decades focused on amyloid-beta in Alzheimer’s disease, researchers are now turning to tau. This protein causes damage…

Skin does not age solely because of the sun or smoking. Deep inside skin cells, a protein that normally prevents damage…

Age-related muscle loss is usually blamed on inactivity or poor diet.

Reducing calorie intake by 30% doesn’t just affect weight. It also appears to slow the pace at which errors accumulate in the…

Wrinkles and reduced skin elasticity are not just cosmetic. They are the visible outcome of years of cellular damage driven by…

Hundreds of tiny proteins active in the brain’s outer layer have been systematically mapped for the first time in people with…

Bone loss after menopause can be slowed significantly. Here are the 5 best proven measures against fractures – and what wastes…

Changing what you eat for just four weeks can measurably lower your biological age. That is the finding of a recently…

A protein that barely appears in the scientific literature turns out to play a direct role in cellular aging.

As kidneys age, senescent immune cells accumulate and damage tissue. Blocking a single protein on the surface of those cells…

The brain has a built-in mechanism to prevent nerve cells from becoming overactive.

Stem cells maintain themselves through a tightly controlled network of signals.

Hundreds of tiny proteins in the brain have been overlooked by scientists for years. A new atlas maps more than a thousand of…

Which lifestyle choices keep your memory sharp after 50? Exercise, sleep, diet and cognitive training: here is what the…

Lung cells respond faster after a previous infection. Not through new genes, but via a component of the innate immune system.

Colorectal cancer cells divide faster when a single inhibitory protein is removed.

Cells can be killed by too much free iron. This form of cell death is called ferroptosis.

The APOE4 gene is the strongest known genetic risk factor for Alzheimer’s disease. But how exactly does it cause damage inside…

Muscles get weaker with age. That much is well known. But a new study identifies a specific molecular culprit: a signaling…

The five best-known longevity influencers run ahead of the science on themselves. Nowhere do they recommend anything with a…

How much fruit and vegetables do you actually need each day? Research across nearly two million people points to five…

Longer nerves break down more easily. That has long been suspected, but the reason remains partly unclear.

Kidney cells that cannot process insulin properly lose more than their metabolism. They also lose the ability to read genes…

A protein that normally helps cells process genetic information may play a key role in Alzheimer’s disease. Reducing its…

The brain’s own immune cells can become damaged with age. When they do, they release a protein that disrupts surrounding brain…

Muscle loss with age is one of the most concrete consequences of growing older. A substance that stimulates muscle growth…

Cancer cells are resourceful. They do not just compete for space and nutrients; they also hijack the molecular signals that…

What if the familiar amyloid plaques are not the first trigger of Alzheimer’s disease, but a different protein is?

Every cell needs ribosomes to make proteins. But under stress, those ribosomes enter a kind of sleep mode.

Alzheimer’s doesn’t start with forgetting. It starts with a microscopic cluster of misfolded protein in your blood, years…

The immune cells that protect your brain can grow old and start secreting something harmful to their neighbours. A newly…

When proteins are built with the wrong components, cells usually suffer for it. Yet female fruit flies with exactly that kind…

After 40, your body burns fewer calories. The main culprit is muscle loss, not some mysterious metabolic slowdown. Here is…

Rebuilding muscle after 60 is possible. Find out exactly what strength training, protein intake and recovery contribute, and…

SGLT2 inhibitors, originally developed to lower blood sugar in diabetes, are known to protect the heart. But exactly how has…

Fatty liver disease affects hundreds of millions of people worldwide, yet the molecular mechanisms that drive fat accumulation…

Autism is linked to hundreds of different gene mutations. Yet many of them produce similar neurodevelopmental outcomes. New…

As we age, the protein-and-fibre network surrounding our cells becomes stiffer. New research suggests that stiffness alone is…

A protein that protects cells from their own DNA turns out, when lost, to cause inflammation and accelerated aging.

What you eat in your first two years of life could influence your health at age seventy.

Eating less slows ageing, but very few people manage to sustain it. Researchers have now identified a specific blood molecule…

Tendon injuries become more common as people age, and recovery takes longer. New research in rats maps out why, and points to…

Four lifestyle factors do the most to lower your cancer risk: not smoking, limiting alcohol, maintaining a healthy weight, and…

Senescent cells keep the body in a state of chronic inflammation. New research shows that a protein normally involved in cell…

There is not one single way to live longer. New genetic research in small roundworms shows that at least three different…

Fat cells that have become senescent release a protein that circulates through the blood. That protein appears to promote…

Researchers recently suggested that reducing protein intake promotes longevity. Nutrition experts are skeptical. For older…

Older skin is chronically mildly inflamed, even without any wound or infection.

Intermittent fasting and caloric restriction: what really works for a longer, healthier life? Here is what the evidence says…

In Alzheimer’s disease, proteins clump together in the brain and destroy nerve cells.

After 50, your immune system starts to lose ground, but you have more influence over the process than you might think. Here…

Women who are more physically active reach menopause later in life. A study of more than 150,000 participants suggests the…

Regular physical activity in your forties and fifties may keep your brain sharper in old age. So does stable blood sugar.

Bryan Johnson's biohacks examined: which interventions have serious evidence behind them, which have been debunked, and where…

A protein that clumps together in Alzheimer’s disease also directly damages the energy-producing structures inside brain…

Older cartilage behaves differently from young cartilage, and researchers now partly know why. A protein that naturally…

High blood pressure is one of the most common health problems in older adults. But why do some people develop it early, while…

ACE2 has long been considered the gateway through which SARS-CoV-2 enters cells.

The tau protein has long been a prime suspect in Alzheimer’s disease.

Could simply shifting when you eat help keep your muscles stronger as you age?

Eating less protein extends lifespan in animals and shows promising signals in humans. Yet official guidelines recommend the…

Muscles gradually lose their ability to repair themselves with age. A new study identifies a protein that drives this repair…

Five different treatments that extend mouse lifespan all raise the same molecule in blood and brain.

Sugar has a bad reputation in today’s nutrition debate. But a new analysis in Science argues that carbohydrates and sugars…

Cancer cells in a poorly perfused tumor receive too few building blocks. That deprivation makes them surprisingly vulnerable…

Tau has long been a prime suspect in Alzheimer’s disease. Now it turns out the protein can also directly sabotage the…

The brain’s ageing is not driven by neurons alone. Their support cells, called glia, play an important role too.

Every cell contains a tiny recycling plant called the lysosome. As we age, these structures begin to fail.

The brain has its own drainage system for metabolic waste. It deteriorates with age, and that deterioration is linked to the…

Restricting food access to an eight-hour window each day increased median lifespan by 12 percent in male mice. That sounds…

The regulation of haem, the iron-containing molecule that gives red blood cells their oxygen-carrying ability, is tighter than…

The gel that fills your eye is not a simple filler. It contains a precisely organised network of collagen fibres, and…

A liver disease linked to obesity and poor diet is usually caught only after serious damage has occurred. A panel of five…

Muscles do not just grow through exercise. There is a built-in brake on muscle growth, and researchers have now clarified how…

Bones weaken as we age. That much is well known. But that the skin plays an active role in this process is new.

A small shift in the amount of a single protein can reshape how heart cells organise their DNA. New research shows this may be…

Which food choices can genuinely strengthen your gut flora? Fibre plays the starring role, but fermented foods and cutting out…

Clumping tau proteins are one of the hallmarks of Alzheimer’s disease. Researchers found a natural cellular protection…

What a father eats before conception influences how his children develop.

Eating less of one specific amino acid can extend lifespan. At least in male mice. The finding raises new questions about how…

When cells produce too many damaged proteins, they come under stress. A built-in emergency programme helps them survive.

For years, Alzheimer’s research focused on amyloid, a protein that clumps in the brain.

Long-term alcohol use damages your DNA through oxidative stress, epigenetic changes, and direct harm to brain cells and sperm.…

Walking, bone broth and calcium are all popular weapons against bone loss, but which ones really deliver? A careful look at…

A protein deep inside mitochondria maintains the genetic material of these energy organelles. With age, it falls out of balance.

Cells are filled with proteins that continuously shuttle between the nucleus and the surrounding cytoplasm. With age, that…

The well-known enzyme that maintains telomeres turns out to do far more than previously thought. It regulates a broad range of…

Proteins that persist in the body for decades slowly accumulate sugar-linked damage. This damage has long been considered…

Older adults who closely follow a Mediterranean diet have higher blood levels of two small proteins linked to heart and brain…

Cells form temporary storage hubs during stress, called stress granules. Researchers assumed these contained only proteins and…

Calorie restriction, omega-3 fats, metformin: nutrition is often pitched as a brake on aging. But does it actually work at the…

In Alzheimer’s disease, a harmful protein spreads through the brain in a predictable pattern. Researchers can now track that…

Back pain from degenerating spinal discs is one of the most common age-related complaints worldwide. Signs can appear before…

White fat cells store energy. That is their function. But what if you could switch them into burning energy instead, like…

For years, Alzheimer’s research focused mainly on amyloid plaques. At the major AAIC conference in London, the spotlight is…

Alzheimer’s disease spreads from cell to cell. Now researchers know which protein holds the door open. Tau proteins accumulate…

Tiny hairs on your lung cells keep your airways clean. When those hairs stop moving properly, chronic disease follows. New…

Most drugs work by blocking a single protein. But a special class of molecules, called molecular glues, works differently.

Twelve weeks of exercise, dietary guidance and probiotic yogurt, and a biological aging clock moved. Can a simple lifestyle…

Ovaries age faster than most other organs. A new study points to a possible reason: a signalling protein that rises with age…

As women age, the tissue around their egg follicles hardens. A specific inflammatory protein drives this process, and blocking…

An experimental Alzheimer’s drug targeting the protein tau has shown promising early results. Detailed data will be presented…

A blood test that predicts chronic disease up to twenty years before diagnosis. New research published in Nature Aging…

Your gut lining renews itself constantly. Two proteins that help cells manage their own building blocks play a larger role in…

How does Alzheimer’s keep reaching new parts of the brain? A common brain protein appears to be ferrying toxic tau fragments…

Older adults who exercise build less muscle than younger people following the same programme. New research points to a…

When algae die en masse, it is not random. They coordinate their own death through a lightning-fast iron-catalyzed chain reaction.

Cells continuously measure how much oxygen is available. That turns out to matter not just during oxygen shortage, but also…

What happens when brain cells lose their self-cleaning mechanism? Researchers long assumed the consequences would be swift and…

Not all immune cells in the liver do the same job. A new study shows that liver-resident immune cells protect themselves…

Semaglutide, caloric restriction, omega-3, and even ketamine all appear on the same list: interventions that measurably lower…

What if drugs already approved for other diseases could also slow aging?

A drug originally developed to help the heart recover after a heart attack may also help kidneys repair themselves after injury.

Cartilage needs low oxygen to survive. A protein that helps cells cope with that environment turns destructive when it stays…

People who live to 100 aren’t just older versions of 80-year-olds. Their blood tells a different biological story.

A protein that accumulates in the bloodstream as we age directly damages bone tissue. Researchers found a way to selectively…

There is a protein in your blood that measurably declines as you age. And as it drops, the risk of cognitive deterioration rises.

A biological clock that simultaneously measures proteins and small molecules in blood predicts chronic diseases more…

A copper-based compound restored the brain’s ability to clear toxic proteins linked to Alzheimer’s disease in laboratory…

How do brain cells replenish their signaling machinery after every transmission? And does that depend on how active they are?…

Evolution has capped the speed of biological processes for billions of years.

Cells constantly sense and respond to mechanical forces from their surroundings.

A protein long studied in autoimmune disease turns out to offer more drug targets than previously thought. And some people are…

In Parkinson’s disease, one damaging protein accumulates inside nerve cells. Researchers have now uncovered a mechanism that…

A protein in brain cells turns out to be critical for Parkinson’s disease.

When cells encounter damaging molecules like free radicals, they normally activate protective programmes. But who gives the…

Large cells die differently from small ones. In a specific form of cell death driven by iron and fat oxidation, bigger cells…

You can eat a generally healthy diet and still suffer cognitively if ultra-processed foods are part of the picture.

A small group of people with a rare inherited mutation live on average seven years longer than others. They lack a working…

Errors in how chromosomes are divided during cell division seem unrelated to metabolism.

Brain cells dispose of waste proteins differently from other cells in the body. A newly discovered system turns out to be…

Collagen is the most abundant protein in the human body. For decades, doctors could not see it on an MRI scan. That has now…

In severe obesity, the heart works differently at the molecular level. A study in Science now shows exactly what changes…

Why do some viruses replicate so efficiently that they overwhelm the immune system?

Top nutrition researchers rarely agree this loudly. Ultra-processed food damages health, they say, and the system producing it…

A protein involved in cellular transport turns out to limit serious brain damage in mice. And it works across two distinct…

Exercise damages your cells. But that damage is precisely what makes you healthier. A protein called HMGB1 appears to be the…

In Alzheimer’s disease, the brain’s immune system stays permanently switched on.

Eating within a fixed daily window improves health in both male and female mice. But only males actually live longer because…

A little-known protein has been shown to extend the lifespan of fruit flies by improving how their cells produce energy.

Scientists keep producing new tools to measure biological aging. The latest uses amino acid levels in blood. But does it…

There is a molecular brake on your DNA repair system. The more active that brake, the faster cells accumulate errors, and the…

The brain has its own immune cells that are supposed to clean up toxic debris, including the protein clumps linked to…

The tau protein, best known for its role in Alzheimer’s disease, appears to be involved in how neurons respond to DNA damage…

A protein best known for helping other proteins fold correctly turns out to play an unexpected role in the cellular response…

One changed letter in a protein’s code can alter everything. New large-scale research maps how amino acid substitutions affect…

Tau protein is best known as a culprit in Alzheimer’s disease. But it turns out to play an entirely different role too:…

Cataracts are among the most common causes of age-related vision loss. New research identifies a specific receptor and protein…

Cells have ways to permanently silence certain genes. One of those guardians is the protein MORC2.

A protein best known from cancer research turns out to play a key role in brain aging.

The same protein accumulates in the brains of patients with more than twenty different diseases.

Cells under stress temporarily halt protein production. That sounds like a useful defence. But researchers found that chronic…

A single blood test that reveals your biological age rather than your calendar age. That is the promise of proteomic aging clocks.

When cells come under stress, they temporarily shut down protein production. That sounds like a useful trick. But researchers…

A single blood test that reveals your biological age rather than your calendar age. That is the promise of proteomic aging…

Older mice with elevated levels of a single protein grew stronger, more energetic, and had healthier bones. Their untreated…

Not all RNA in the cell makes proteins. Much of it stays untranslated and regulates other genes instead.

Critics have warned that GLP-1 drugs strip away more muscle than ordinary dieting. A new study puts that concern in perspective.

Neurons must survive for decades without dividing. That makes DNA repair critical, and a new study shows one key repair…

A dietary amino acid shapes gut barrier function and immune regulation through a microbial pathway that has only recently been…

Drinking two to three cups of coffee a day is associated with a 35 percent lower risk of dementia.

Muscle loss in older age isn’t just about inactivity or poor diet.

In ALS and a form of frontotemporal dementia, a protein called TDP-43 clumps together in nerve cells, and kills them.

Your body is full of proteins that have been chemically modified by sugar, not because of what you eat, but because of basic…

The bacterial community living in your gut shifts as you age, becoming less diverse, more inflammatory. For years, researchers…

Imagine a trial on a dietary intervention finding that participants become biologically younger.

Every cell in your body lives inside a kind of scaffolding, a web of proteins that provides structure, relays signals, and…

When a key energy-producing protein is reduced in cancer cells, the tumors don’t slow down, they accelerate. New research…

A protein that normally powers every cell in your body does something surprising in cancer cells: when it becomes less active,…

Lung fibrosis replaces healthy tissue with scar tissue, makes breathing progressively harder, and has almost no treatments…

Lung fibrosis is one of the hardest age-related diseases to treat. Scar tissue replaces healthy lung tissue, breathing grows…

Every cell in the body follows a tightly regulated cycle of growth and division. When that regulation breaks down, cancer follows.

Your brain has a built-in system for clearing out damaged proteins.

Life on Earth uses twenty amino acids to build every protein in every living thing. Researchers wondered whether all twenty…

A worm barely a millimeter long can sniff out bacteria enriched with a specific amino acid it cannot make itself.

Researchers have identified a molecular switch inside the body’s blood-forming cells that gets triggered by stress and appears…

The most advanced Alzheimer’s treatments ever developed can now demonstrably remove the protein clumps long blamed for the…

Scientists have reprogrammed blood stem cells to generate a continuous supply of protective proteins, potentially for the…

What if the body’s own cells could be reprogrammed as tiny factories, producing exactly the protein a patient needs at the…

Periodic fasting has been promoted for years as a powerful way to improve metabolism. But how the body actually responds…

Ribosomes are the molecular machines inside every cell that build proteins. They were long thought to work identically in…

AI models that study proteins have a blind spot: they learn from data without understanding how evolution actually works.

People with a particular inherited eye disease go slowly blind, starting with their central vision. For decades, the exact…

Every cell in your body is constantly building proteins, the molecules that do nearly everything. But exactly how that…

A one-time treatment that makes your body produce its own medicines, for life.

Scientists have known for decades that cutting calories extends lifespan in mice.

A fragment of a protein that normally helps organise the cell’s genetic material can create small, temporary gaps in DNA, and…

Tau protein is present in almost every brain over the age of eighty, yet most people never develop dementia.

Tuberculosis kills more people each year than almost any other infectious disease. The bacterium survives by hiding inside the…

Blood cancer cells cloak themselves in a layer of sugar molecules that tells the immune system to stand down.

Cancer cells are skilled escape artists. But leukemia cells have a particularly elegant trick: they coat themselves in sugar…

Nearly every older person has it in some form: a protein that slowly misfolds and accumulates in the heart and other organs.

You could follow the most nutritious diet imaginable, but if your first meal comes late in the day and your last one lands…

Every cell contains millions of proteins that must be in exactly the right place at the right time.

Instead of targeting amyloid or tau, the usual suspects in Alzheimer’s research, scientists focused on a neuropeptide that had…

Proteins are the machines of life, and designing new ones from scratch used to take years of painstaking work. AI has upended…

You could follow every dietary guideline perfectly, but if you’re eating dinner at 10 pm, your cells may be aging faster…

Proteins are the machinery of life, and designing new, artificial ones was a slow and expensive craft for decades. AI has…

You can eat exactly what the dietary guidelines recommend, but if you do it at eleven o'clock at night, your body ages faster.

Worn-down spinal discs are behind much of the back pain that becomes nearly universal with age.

The way people eat is simultaneously one of the largest drivers of chronic disease and one of the largest contributors to…

Spinal disc degeneration is one of the most common causes of chronic lower back pain in older people, and so far, there is…

For decades, atrial fibrillation and heart failure have been treated as entirely separate diseases.

The way people eat is simultaneously one of the biggest drivers of chronic disease and one of the biggest drivers of climate…

Atrial fibrillation and heart failure have been treated as two separate diseases for decades.

Proteins are fragile. Heat, acid, mechanical stress, they deform and fall apart.

Proteins are fragile structures. Heat, acid, mechanical stress: they warp or fall apart. But what if you could build a protein…

Restricting protein triggers a conversion of white fat into brown fat, a metabolically healthier tissue type. But the body…

They are not neurons and they rarely get the attention, but astrocytes are everywhere in the brain and they do almost…

Misfolded proteins are among the leading drivers of age-related diseases, from Alzheimer's to Parkinson's. We know more and…

Almost everyone loses muscle mass and strength with age. That is not simply a matter of moving less; deep inside muscle…

Scientists have uncovered a fundamentally new principle behind how your immune system senses danger and responds at lightning…

Caloric restriction, fasting, protein restriction: dietary interventions have captured the attention of aging researchers for…