Aging clocks
Biological age, epigenetic clocks and biomarkers of aging.
80 answers, from 561 studies
Last updated: October 2026
Key questions
Can nucleotides lower your biological age?
NAD+ supplements measurably raise NAD+ levels in your blood and, in one study, prevented biological age from rising, but did…
Preliminary evidence
How does your immune system age and can a blood test measure that?
Your immune system ages in recognisable ways: exhausted immune cells and smouldering inflammation are clearly visible…
Preliminary evidence
What do biological ageing clocks actually measure?
Biological ageing clocks measure methylation patterns on your DNA and show that loss of cell identity resets the counter to…
How reliable is a protein test for measuring your biological age?
A protein test is a promising and now reasonably well-supported way to measure biological ageing, particularly as a predictor…
What does your vascular age tell you about your health?
A high vascular age on the measurement is a serious signal: your risk of cardiovascular disease, dementia, and premature death…
Is a clinic package for biological age worth the extra cost?
A clinic package can capture more than a single test, but only if it combines the right, newer markers. As long as reference…
Moderate evidence
Which DNA clock is best: GrimAge, DunedinPACE or PhenoAge?
GrimAge2 has the strongest evidence base for predicting mortality and healthy life years. If you want to know which clock…
Moderate evidence
Does a biological age test give the same result twice?
The same test yields reasonably consistent results when repeated, but different tests do not measure the same thing and are…
How often does it make sense to remeasure your biological age?
Clocks change slowly: two years is a realistic minimum to see the effect of a lifestyle change, but whether a lower score…
Moderate evidence
What do you do with the result of a biological age test?
A biological age higher than your calendar age is a signal, not a diagnosis. Use the result as a reason to examine your…
Preliminary evidence
Does the PhenoAge test measure your biological age with standard blood values?
Standard blood test results can provide an estimate of your biological age through PhenoAge, and that estimate predicts health…
How reliable is a GlycanAge test for measuring your biological age?
GlycanAge measures something real, but whether the score reliably reflects your biological age has not yet been independently…
Can semaglutide slow down the ageing process?
There are early encouraging signs that semaglutide may be able to slow biological ageing, but the clinical evidence comes from…
Preliminary evidence
Does alpha-ketoglutarate work against ageing?
In animal research AKG clearly extends lifespan, but solid evidence in humans is still lacking. Wait for the results of the…
Preliminary evidence
What can you expect from a longevity clinic in the Netherlands?
A longevity clinic can offer you interesting measurements of your health markers and a good exercise programme. For most…
Preliminary evidence
Does your telomere length tell you anything useful about your health?
Telomere length is a relevant biological measure, but does not give a clear-cut signal: shorter telomeres increase the risk of…
Do epigenetic clocks vary so much that your result is just chance?
Epigenetic clocks can diverge substantially for the same purpose, so your result does genuinely depend on which clock is used.…
Can epigenetic reprogramming reverse ageing?
Epigenetic reprogramming consistently and convincingly rejuvenates cells and tissues in animal and laboratory studies, but no…
Preliminary evidence
What does your klotho level tell you about how fast you are ageing?
A low klotho level is associated with a higher risk of death in older age, but as a personal measure of ageing speed the test…
What do we know about rapamycin as an anti-ageing agent in humans?
Rapamycin shows measurable improvements in immune function and cellular ageing markers in people. Whether it also extends…
Does plasma exchange (plasmapheresis) work against ageing?
There are initial, cautiously positive indications from one small study, but it is too small and too influenced by commercial…
Preliminary evidence
Does calcium-AKG lower your biological age?
Reliable evidence that calcium AKG lowers biological age in humans is lacking. The well-known claim of 8 years comes from a…
Preliminary evidence
Why does the risk of cancer increase with age?
Cancer becomes more common with age because DNA damage accumulates, the immune system declines, and damaged dormant cells can…
Can you lengthen your telomeres through lifestyle?
Lifestyle can probably slow telomere shortening, but the starting length of your telomeres is largely genetically determined…
Yes · Moderate evidence
Does your body age faster after a prolonged period of stress?
Prolonged stress is associated with signs of faster cellular ageing, but whether this is truly causal and applies to everyone…
Does your body odour change as you get older?
Yes, your body odour changes noticeably with age: from your forties onwards your skin produces a compound that adds a greasy,…
How reliable are the biological age tests you can buy online?
Biological age tests are scientifically grounded when applied to large groups, but what a score means for you personally has…
Does your resting heart rate say anything about how fast you are ageing?
A structurally high resting heart rate, certainly above 80 to 90 beats per minute, is associated with a clearly higher risk of…
How reliable is an epigenetic age test?
An epigenetic age test provides a meaningful indication of biological ageing, but is not yet a definitive verdict on your…
Moderate evidence
Does the country you live in affect your biological age?
The country you live in probably influences biological ageing markers through diet and living conditions, but direct…
Can you see how fast you are ageing from your stool?
Your microbiome does change with age and is associated with health risks, but a reliable ageing test based on stool does not…
Moderate evidence
Do your kidneys age at a different rate than your liver?
The kidneys age measurably faster than the liver, but for most healthy people that decline only has major consequences when…
Can you influence your epigenetic age through diet?
Multiple studies show that a healthy dietary pattern can favourably influence your epigenetic age, although these are…
Yes · Moderate evidence
What does too much sitting do to your biological clock?
Too much sitting demonstrably weakens your day-night rhythm, even after just one day. Moving more, and preferably in the…
Does your biological age advance more quickly when you are lonely?
Loneliness is associated with measurably faster biological ageing, and that association has been found across multiple…
Can you see your biological age in your blood pressure?
A rising systolic blood pressure and a widening gap between the upper and lower numbers are recognisable signs of vascular…
How reliable is a saliva test for biological age?
A saliva test provides a reasonable estimate of your calendar age, but does not measure exactly the same thing as a blood test…
Do you age faster if you have chronic pain?
Whether chronic pain makes you age faster depends strongly on the type of pain, the accompanying stress and depression, and…
Can your microbiome reveal how old you are biologically?
The bacteria in your gut change in recognisable ways with age and are linked to how healthily you grow old. The early evidence…
What is DunedinPACE and what does it tell us about ageing?
DunedinPACE measures how quickly you are ageing biologically and is associated with disease and premature death, but the test…
Does diabetes make a person age faster biologically?
Yes, diabetes measurably accelerates biological ageing: the risk of cardiovascular disease, dementia and early death…
Which blood markers can tell you how fast you are biologically ageing?
Blood markers such as protein profiles, DNA-tag patterns, telomere length and standard inflammation markers each offer their…
What does alcohol do to your biological age?
Alcohol accelerates multiple biological ageing processes, including gut damage, inflammation, and brain deterioration. The…
Is it true that women age more slowly biologically than men?
Multiple studies confirm that women are biologically younger than men of the same age, but women also spend their extra years…
Can meditation slow your biological clock?
Research shows that meditation has a beneficial effect on telomerase activity, an enzyme that protects cells from ageing. In…
Preliminary evidence
Does your biological age change differently at night than during the day?
The night is biologically not a pause but an active recovery phase, and that phase deteriorates noticeably with age. Those who…
Does the time you eat affect your ageing?
The time at which you eat does appear to matter, although the evidence in humans is still associative. A nightly fasting…
Yes · Moderate evidence
What is the Horvath clock and why is it so well known?
The Horvath clock was the first biological age measure that worked broadly across virtually all tissues, and that is what…
How quickly can you change your biological age with exercise?
Regular moderate to vigorous exercise is associated with a biological age that comes out 1 to 3 years lower, and molecular…
Moderate evidence
Can a blood test reveal how old your organs are?
A blood test can estimate the biological age of individual organs, and accelerated ageing is clearly associated with more…
Does your skin age faster than your organs?
It has not been proven that skin as an organ naturally ages faster than your internal organs, but it is more vulnerable to sun…
Do your cells actually get younger when you restrict calories?
Calorie restriction demonstrably slows the biological rate of ageing in cells, including in people. An approach such as the…
What does smoking do to your biological age?
Smoking measurably accelerates the biological ageing of lung cells, the immune system, and the reproductive system. Stopping…
Can fasting turn back your biological age?
Fasting, particularly intermittent fasting and ketogenic diets, moves multiple biological ageing markers in a favourable…
Moderate evidence
What does an epigenetic clock actually measure?
An epigenetic clock reads chemical labels on your DNA to estimate your biological age, which already says something about your…
Does insulin resistance accelerate ageing?
Insulin resistance is associated with measurably faster biological ageing, greater muscle loss, and possibly a higher risk of…
Yes · Moderate evidence
How do telomeres protect your DNA?
Telomeres protect your chromosome ends through a system of proteins that simultaneously prevents false alarms and harmful…
Why do your telomeres get shorter as you age?
Telomeres shorten because the copying process during cell division cannot fully reproduce the ends of chromosomes, and the…
Does NAD+ supplementation slow biological ageing?
NAD+ supplements reliably raise your blood levels. Whether that also slows biological ageing has not yet been demonstrated in…
No · Preliminary evidence
What is the difference between living longer and living longer in good health?
Healthspan and lifespan are two separate things: you can live a long time yet lose years to illness and decline. Calorie…
What does the stress hormone cortisol do to my ageing?
Chronically elevated cortisol accelerates muscle loss and disrupts your metabolism, and that effect is real. Good sleep and…
Can you have your telomeres measured, and is there any value in doing so?
A telomere test is technically possible but currently provides little actionable information for you as an individual, because…
Yes · Moderate evidence
Do I inherit my life expectancy from my parents?
Genetics explains roughly one third of how long you live, so your parents give you a biological starting point, not a…
Do people age through different organs?
Yes, people age through different organ pathways. The science needed to map this precisely for each individual is promising,…
Can you tell someone's biological age from their face?
Your face does emit biological signals, but it is too limited and too variable to measure your biological age accurately. Take…
Does everyone age at the same rate?
At the molecular level everyone ages at a broadly similar baseline rate, but in terms of health and life expectancy people can…
Does my walking speed say anything about how fast I am ageing?
Yes, your walking speed says something about how your body is ageing. People who walk slower than 0.8 to 1.0 metres per second…
How big is the difference between your biological and calendar age?
The typical spread between your biological and calendar age is around one to two years. Studies name no firm upper limit, but…
What is young blood / plasma exchange, and does it actually work?
Plasma exchange clearly works in mice, but in humans there is still no evidence whatsoever of efficacy or safety. Do not be…
Preliminary evidence
Does hyperbaric oxygen therapy help against ageing?
HBOT shows interesting signals in small, early studies regarding telomere length and cerebral blood flow, but the evidence is…
Preliminary evidence
Are DNA methylation tests for biological age worth the money?
The underlying technology has scientific merit, but commercial tests have not yet been independently validated and the…
Moderate evidence
Can you really lower your biological age, and does research support this?
There are promising hints that biological age is measurable and perhaps steerable, but this has not been proven. Wait for…
Preliminary evidence
How reliable are epigenetic clocks?
Epigenetic clocks are reliable predictors of health risks and the chance of dying sooner, but as an individual measurement…
Which lifestyle factors influence your biological age the most?
Sitting for prolonged periods, a disrupted circadian rhythm and muscle loss are the best-supported negative factors for your…
Moderate evidence
What does your VO2max say about how fast you are ageing?
A higher VO2max is strongly associated with lower mortality and a more favourable biological age, but is more of a gauge of…
How can I measure my biological age?
Epigenetic clocks, particularly GrimAge and PhenoAge, currently offer the best estimate of your biological age, but they are…
Moderate evidence
How does ageing work and how can you slow it down?
Ageing is well described biologically, but there are no proven means of genuinely slowing it in humans yet. For now, focus on…
Moderate evidence
Are biological age tests actually accurate?
Biological age tests such as GrimAge and DunedinPACE are associated with health outcomes in scientific research, but no…
Moderate evidence
What are telomeres and can I keep them longer?
Telomeres protect your genetic material, and they shorten over the years, largely determined by your genes. Whether you can…
Strong evidence
Does stress make you age faster?
Prolonged stress measurably accelerates your biological ageing. Healthy habits can noticeably slow that process.
Latest articles
25 OctDNA regulation drives aging but is not the only engine
Aging does not have a single cause. But one mechanism sits at the top: changes in how genes are switched on and off.
1 min
Aging clocks are only reliable when several agree
Scientists use aging clocks to measure whether a therapy lowers biological age. But new analysis shows that a single positive…
1 min
Ten healthy diets all linked to slower biological aging
What if there isn’t one ideal diet, but ten? New research suggests that multiple healthy eating patterns are associated with…
1 min
AI finds undiagnosed conditions hidden in routine CT scans
A CT scan is made to answer one clinical question. But the images contain far more information than any radiologist can…
1 min
Gut microbiome predicts inflammation better than age
Your gut bacteria may say more about your health than your birth year.
2 min
Splicing factor SRSF1 slows aging in worms and mice
What if you could roll back the biological age of a cell without erasing its identity? That may sound far-fetched, but…
1 min
Resting brain waves shift measurably with age
The way the resting brain generates electrical signals changes as people grow older. Researchers have now managed to measure…
2 min
Which body measurements best predict early death
Which measurement of your body best predicts how long you will live?
1 min
Body size shapes how fast dogs age, molecularly
Large dogs live shorter lives than small dogs. Dog owners have known this for decades. But why? New research uncovers a…
1 min
Aging follows a different path in each person
Everyone ages, but no one ages the same way. New research shows how strongly individual aging patterns diverge, even among…
2 min
Speech reveals how fast the brain ages
The way someone talks reveals more about the state of their brain than you might expect. Researchers have now used it to build…
2 min
AI reads aging in blood stem cell nuclei
You can tell how biologically old someone is by looking inside a blood stem cell.
2 min
Fat inside muscles may measure how fast you age
You can see aging in your muscles. Not just in how much muscle you have, but in how much fat has crept in between the fibers.
2 min
Longer fatty acid chains mark aging across species
Cells change their fat composition as they age. A new study in Nature Aging shows that fatty acids, the building blocks of…
1 min
Faster biological aging at forty predicts memory loss
People who age biologically faster in their forties report more memory problems a decade later.
2 min
Longevity products need smarter regulation
The market for products claiming to slow aging is growing fast. But the rules for testing and approving them have not kept pace.
1 min
The body clock controls fat metabolism in fat cells
The body has an internal clock that governs almost every cell.
1 min
Transplanted hearts age with their recipient
A young heart placed in an old body becomes molecularly older. An old heart placed in a young body becomes molecularly younger.
2 min
Aging biomarkers take center stage at Shanghai longevity forum
How do you measure whether an anti-aging treatment works without waiting decades for results? That was the central question at…
2 min
Hormone levels in a blood test: what does your result actually tell you?
Which hormone values are worth testing, what can you ask your doctor to measure, and what costs money without adding value? A…
4 min
Blood test measures total burden of aging cells
Aging cells release harmful substances that drive inflammation and damage tissue. Until now, there was no reliable way to…
2 min
New atlas maps aging in individual kidney cells
Scientists have mapped for the first time how individual kidney cells age, in both humans and mice.
1 min
Blood test screens for dozens of cancers at once
A blood test that screens for more than fifty types of cancer simultaneously has cleared a key FDA advisory committee. Ten…
1 min
Grip strength tests gene therapy for aging
Your hand grip strength reveals more about your health than most people realize. Now it is being used to measure something…
2 min
Younger generations are aging faster biologically
People who are forty today appear biologically older than forty-year-olds were a generation ago. That is not a marketing claim.
1 min
Lung drug makes blood look younger on six clocks
An experimental lung fibrosis drug did something unexpected: it made patients’ blood appear biologically younger. Researchers…
2 min
Diet lowers biological age in just four weeks
Changing what you eat for just four weeks can measurably lower your biological age. That is the finding of a recently…
1 min
Aging clocks respond differently to the same treatment
Scientists want to know whether an intervention genuinely slows aging. But the measurement tools they use give different…
2 min
Aging clocks may not measure the same thing
Dozens of tests claim to measure your biological age. But are they actually measuring the same thing? A comprehensive review…
2 min
Longevity science is losing the public messaging battle
Cardiology spent decades teaching the public what blood pressure and cholesterol numbers mean.
2 min
Blood test may detect cervical cancer recurrence earlier
After treatment for cervical cancer, the key question is whether the disease will return. A blood test based on freely…
1 min
Genes and metabolism shift in measurable aging patterns
What does human aging actually look like, measured from the inside?
1 min
Measuring biological age: which tests actually mean something, and which don't
Epigenetic clocks, saliva tests, blood chemistry: which measure of your biological age is reliable, what can your doctor offer…
3 min
What aging clocks can learn from clinical trials
Biological aging clocks are among the most discussed tools in longevity science. But how well do they perform as measuring…
2 min
A blood test detects Alzheimer’s seeds early
Alzheimer’s doesn’t start with forgetting. It starts with a microscopic cluster of misfolded protein in your blood, years…
1 min
Dogs may hold clues to human aging
Dogs live only a fraction of a human lifespan, but they appear to age in remarkably similar ways.
1 min
Tissue scans reveal each organ ages differently
Not every organ ages at the same pace. A new framework scans tissue images from dozens of organs and measures biological age…
2 min
Disrupted body clock accelerates muscle loss with age
Losing muscle mass is one of the most underestimated consequences of aging.
2 min
Wearables can catch illness before symptoms appear
Medicine usually waits for you to get sick before measuring anything. But what if your body signals a problem weeks earlier?
2 min
Disrupted body clocks may drive age-related muscle loss
There are still no approved drugs for sarcopenia, the age-related loss of muscle mass and strength. A new analysis suggests a…
1 min
Aging clocks for men and women differ sharply
Men and women do not age in the same way. A new study developed separate biological aging clocks for each sex and found…
1 min
Early sugar exposure may shape aging decades later
What you eat in your first two years of life could influence your health at age seventy.
2 min
Tissue scans reveal biological age of 40 organs
Microscope slides of organ tissue can reveal how biologically old that organ is. Researchers trained an algorithm on more than…
1 min
Sleep too little or too much? Cells age faster
Too little sleep is well-known to be unhealthy. But sleeping too much appears to accelerate biological aging as well.
1 min
Blood metabolites could sharpen biological age measurement
How do you know whether an anti-aging intervention actually works? Right now, that is nearly impossible to measure quickly.
2 min
Brain aging clocks: where the science stands
Your brain may be biologically older than your birth certificate suggests. Scientists are building clocks to measure that gap,…
2 min
A smarter aging clock targets older adults
Most biological aging clocks are trained on chronological age, but that introduces a hidden flaw: people who are still alive…
2 min
Chronic inflammation explains up to a quarter of aging risk
How large is the role of chronic inflammation in aging? Larger than many assume, but also smaller than some researchers hope.…
2 min
New aging clock reads gene activity, not DNA
Measuring biological age is hard. The best-known methods look at chemical marks on DNA.
1 min
Biological age predicts death risk after surgery
Two people of the same age can be worlds apart biologically. A new multi-cohort study suggests that difference matters most…
1 min
Brief stress can skew your biological age test
Biological age tests based on DNA methylation are often called the gold standard of aging measurement. But a new study…
1 min
Aging clocks misread biological age in mixed-ancestry groups
Tests that estimate biological age using chemical marks on DNA perform poorly in people with mixed genetic ancestry.
1 min
Blood cell cloning accelerates biological ageing
Some people carry a silent time bomb in their blood: stem cells with a small genetic mutation that gradually multiply and take…
1 min
Blood test predicts liver disease sixteen years early
A blood test could predict who will develop liver disease up to sixteen years before diagnosis.
2 min
Digital tests could detect Alzheimer far earlier
Blood tests for Alzheimer’s are improving rapidly. But the cognitive assessments doctors use have barely changed. A commentary…
2 min
Poor sleep correlates with aging, but may not cause it
Poor sleep quality is strongly linked to faster biological aging. But does bad sleep actually cause that acceleration?
2 min
Gut bacteria composition correlates with biological age
Your gut bacteria and your biological age are closely linked.
1 min
Blood stem cell mutations accelerate biological aging
Your blood cells may be biologically older than your calendar age. New research links a common age-related mutation pattern in…
2 min
Aging clocks now measure biological age organ by organ
Your passport records when you were born. But how old are your cells really? A new generation of biological aging clocks is…
2 min
Blood test reliably tells three dementias apart
A blood test that can distinguish three forms of dementia from one another: it sounds futuristic, but a large international…
2 min
Ozempic slows biological ageing markers in people with HIV
Semaglutide, the active ingredient in Ozempic and Wegovy, appears to slow biological ageing markers in adults with HIV. This…
1 min
Repeated ageing clock readings predict mortality better
A single ageing clock measurement tells you relatively little.
2 min
Targeting senescent cells cuts post-chemo inflammation
Chemotherapy saves lives but accelerates biological ageing in the body.
1 min
Underground lab tests cosmic rays and DNA aging
What if part of aging is caused by cosmic particles shooting through us every second?
1 min
Lifestyle slows biological aging on the clock
Twelve weeks of exercise, dietary guidance and probiotic yogurt, and a biological aging clock moved. Can a simple lifestyle…
2 min
Fruit flies actively reset their own body clock
Your biological clock ticks around the clock, but what happens when it falls out of sync?
1 min
Why mice age fast and humans age slowly
Mice and humans both age, but the underlying process differs fundamentally. Researchers have now built a mathematical model…
2 min
Blood test maps senescent cells tissue by tissue
Senescent cells accumulate in the body and cause damage. Until now, measuring which tissues are most affected has been difficult.
2 min
Blood protein clock predicts disease two decades early
A blood test that predicts chronic disease up to twenty years before diagnosis. New research published in Nature Aging…
2 min
DNA accessibility in immune cells tracks ageing
Not all cells read their DNA the same way. How a cell responds to disease depends partly on which stretches of its DNA are…
2 min
Each cell type ages at its own pace
Your body doesn’t age uniformly. Some cell types are biologically far older than others, and that gap may determine which…
2 min
Longevity contest tracks who ages slowest
What if hundreds of people could simultaneously test who is best at rolling back their biological age? That is the premise…
2 min
Faster biological aging predicts early-onset cancer
Younger generations are biologically older than their parents were at the same age.
2 min
Insurers want to know your biological age
Imagine you are 50 years old, but your biological age is 46. Would that mean a lower insurance premium? Life insurers are…
2 min
41 interventions that lower your biological age
Semaglutide, caloric restriction, omega-3, and even ketamine all appear on the same list: interventions that measurably lower…
2 min
DNA tags reveal how aging differs across body tissues
Your skin ages differently from your liver. Your muscle tissue follows a different pattern than your brain. But there are also…
2 min
Are GLP-1 drugs actually slowing down aging?
GLP-1 receptor agonists are widely used for obesity and diabetes. But could they do something more fundamental, actually…
1 min
New aging clock reads immune cells one by one
Aging clocks measure how old you are biologically. Most look at chemical tags on your DNA.
2 min
New aging clock merges proteins and metabolites
A biological clock that simultaneously measures proteins and small molecules in blood predicts chronic diseases more…
2 min
DNA repair capacity tracks with animal lifespan
Whales can live for centuries. Mice barely make three years. New comparative data point to a surprisingly direct explanation:…
2 min
The placenta keeps its own biological time
The placenta, the organ that sustains a foetus throughout pregnancy, appears to have its own internal clock. Researchers…
1 min
Your liver reveals your true biological age
A new measure of biological aging looks not at your brain or your blood cells, but at your liver. And it predicts mortality…
2 min
A new model explains why lifespans vary so much
Why do humans live for decades while other mammals age out in a few years? A new mathematical model offers the first unified…
1 min
One enzyme sets the pace of your body clock
Your body clock ticks like a watch, but that watch only keeps time because one enzyme is in the right place. New findings…
1 min
GLP-1 drug measurably slows biological aging
A widely used weight-loss drug does more than shed pounds. Researchers found that semaglutide also slows biological aging, as…
2 min
Damage accumulation splits ageing into two regimes
Why do some animals live for a few weeks and others for hundreds of years?
1 min
An open contest to find better aging clocks
We already know that biological age differs from chronological age. But how do you measure it reliably? Scientists disagree.…
1 min
Eggs reset biological age at every generation
A newborn is biologically zero years old, even if its mother is fifty. The egg cell does something no other cell in the body…
2 min
One aging clock works in mice and humans
Most tests that measure how fast you age only work in humans. So how do you know whether an anti-aging treatment that works in…
1 min
Gene networks reveal patterns in ageing
Which genes actually drive how fast you age? Researchers built a network of genes associated with ageing and found two clearly…
2 min
A blood test for multiple cancers underdelivers in trial
A blood test that screens for multiple cancers at once sounded like a turning point. A large randomised trial in the UK tells…
1 min
Time-restricted eating extends lifespan in male mice
Eating within a fixed daily window improves health in both male and female mice. But only males actually live longer because…
2 min
One protein makes fruit flies live longer
A little-known protein has been shown to extend the lifespan of fruit flies by improving how their cells produce energy.
2 min
Germ cells age you differently depending on sex
The cells that make eggs and sperm do more than enable reproduction. They also send signals that control how fast the rest of…
2 min
Kidney decline and frailty form a feedback loop
Organs do not age in isolation. As kidney function drops, the rest of the body follows. New research maps how renal decline…
2 min
A blood test for aging built on amino acids
Scientists keep producing new tools to measure biological aging. The latest uses amino acid levels in blood. But does it…
2 min
One protein complex controls how long you live
There is a molecular brake on your DNA repair system. The more active that brake, the faster cells accumulate errors, and the…
2 min
Scientists still can’t agree on how to measure body wear
The idea is straightforward: a body that has endured years of stress is more worn down than one that hasn’t.
2 min
Stretchable sensor tracks body signals without breaking
A new material can measure electrochemical signals from living tissue while stretching with the skin or muscle beneath it.…
1 min
Why aging clocks need multiple data layers
A single biological measurement tells you one piece of the aging story. Researchers now argue that combining multiple layers…
2 min
Menin protein controls brain aging in hypothalamus
A protein best known from cancer research turns out to play a key role in brain aging.
1 min
Retinal aging clock tracks osteoporosis progression
A scan of the retina can reveal more than eye health. New research shows that an aging clock based on retinal images…
2 min
Organ-specific aging clocks measure each organ separately
Your liver can be ten years older than your heart, while your calendar age gives the same number for both. New aging clocks…
2 min
Blood proteins estimate biological age reliably
A single blood test that reveals your biological age rather than your calendar age. That is the promise of proteomic aging clocks.
1 min
Protein clocks measure biological age in blood
A single blood test that reveals your biological age rather than your calendar age. That is the promise of proteomic aging…
1 min
One MRI scan predicts Alzheimer’s progression
A single brain scan and an algorithm. That combination may be enough to predict whether someone will develop Alzheimer’s, how…
2 min
Urine test tracks tissue senescence after injection
Measuring tissue aging usually requires a biopsy or imaging scan. A newly developed probe could make it as simple as…
2 min
Fitness leaves epigenetic clocks nearly unchanged
People in excellent physical condition score almost identically to sedentary peers on most mainstream epigenetic aging clocks.…
2 min
Urine reveals tissue senescence non-invasively
Detecting the buildup of aging cells in the body has always required invasive tissue samples. A new study suggests a simple…
2 min
Weightlessness accelerates aging like a fast-forward
Scientists studying aging face one persistent obstacle: it takes a long time for animals to grow old. An unlikely solution is…
1 min
How Your Gut Ages, and Rolls Out the Welcome Mat for Harmful Bacteria
Something fundamental shifts in your gut as you age, and that shift makes it easier for dangerous bacteria to take hold.…
2 min
Napping in old age: harmless habit or warning sign?
Millions of older adults take daytime naps and feel better for it. But a new study links longer and more frequent napping to a…
2 min
Female organs age at their own pace, and menopause is the turning point
The uterus, ovaries and fallopian tubes each follow their own biological clock.
2 min
Early cancer detection from routine blood tubes: closer than we thought
Early cancer detection through a blood test, the so-called liquid biopsy, is one of the most promising developments in…
1 min
Living at high altitude ages your immune system faster
People living at high altitude have less oxygen available. That has a surprising consequence: their immune systems appear…
2 min
Naked mole-rats age for decades without their gut bacteria changing, that’s almost unheard of
In most mammals, the community of bacteria living in the gut shifts dramatically with age.
2 min
Dirty air may be aging your cells faster than the years on your passport
Air pollution has long been linked to heart disease, lung damage, and cancer.
2 min
Chronic inflammation and the biological aging clock are more intertwined than we thought
Two of the most discussed phenomena in aging research, chronic low-grade inflammation and the biological clock of cells, are…
2 min
Chronic inflammation and biological aging are more deeply intertwined than we thought
Two of the most talked-about phenomena in aging research, chronic low-grade inflammation and the biological clock of cells,…
2 min
A longevity gene in flies works partly through gut bacteria
A gene associated with longer lifespan in fruit flies for decades appears to work partly through the animal’s gut bacteria.
2 min
Inflammation and biological age are intertwined, but which one drives the other?
Two of the most discussed processes in aging science, chronic low-grade inflammation and epigenetic changes in DNA, turn out…
2 min
Ribosomes differ between people and that may help explain why we age so differently
Ribosomes are the molecular machines inside every cell that build proteins. They were long thought to work identically in…
2 min
Silent inflammation speeds up biological aging, new research shows exactly how
Your body can be biologically older or younger than your birth certificate suggests, and a type of inflammation you never feel…
2 min
Ancient viral leftovers in your DNA are waking up, and that may be aging you
Nearly half of the human genome consists of remnants from ancient viral infections. In youth, cells keep these sequences…
2 min
Your immune system ages, and that makes every flu season more dangerous
Older people don’t die from the flu more often simply because they’re frail.
2 min
When you eat may age you faster than what you eat
You could follow the most nutritious diet imaginable, but if your first meal comes late in the day and your last one lands…
2 min
The first trial to reprogram human cells younger: is the FDA finally treating aging as a disease?
Life Biosciences is about to become the first company to test a therapy that makes cells biologically younger, not as a…
2 min
Women’s immune systems age more dramatically than men’s, and science is only now catching up
Immunity doesn’t age the same way in everyone. A new study of nearly a thousand people reveals that women and men follow…
2 min
The first experiment to make human eyes biologically younger has begun
A biotech company has received FDA clearance to begin resetting the biological clock in human eye tissue.
2 min
Women’s immune systems age more broadly than men’s
Same species, same lifespan pressures, but the immune system ages in strikingly different ways depending on whether you’re…
1 min
Turning back the clock on cells, the FDA says yes
The US drug regulator does not officially recognise ageing as a disease. Yet this year, for the first time, a therapy designed…
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The first therapy designed to make human cells biologically younger is entering clinical trials
For the first time, a treatment that resets the biological age of cells is moving into human trials.
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When you eat may matter as much as what you eat, at least for how fast you age
You could follow every dietary guideline perfectly, but if you’re eating dinner at 10 pm, your cells may be aging faster…
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Late meals speed up biological aging
You can eat exactly what the dietary guidelines recommend, but if you do it at eleven o'clock at night, your body ages faster.
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Mapping the DNA inside our energy factories, one cell at a time
Mitochondria have their own DNA, and errors in it accumulate as we age.
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The first human trial of cell reprogramming starts this month, and it begins with the eye
A small biotech company is about to test whether ageing cells can literally be ‘rewound’ in living humans. If it works in the…
2 min
How mitochondria distribute their DNA, and why getting it wrong drives aging
Mitochondria, the energy generators inside our cells, carry their own DNA, separate from the cell’s nucleus.
2 min
Alzheimer’s Blood Tests Are Going Mainstream, and Scientists Are Nervous
A blood test that can detect Alzheimer’s disease years before symptoms appear sounds like unambiguous progress.
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Gut microbiome aging clocks: do they actually measure biological age?
Take enough data from enough people, run an algorithm over it, and you have an aging clock. That now applies to the gut…
2 min
Biological age tests: scientific tool or glorified horoscope?
A simple blood test that doesn't measure your birthday but your "real" age: how old your body actually is.
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Biological Age Tests Are Booming. The Science Is More Complicated Than the Marketing
Patients are arriving at clinics clutching reports of their ‘biological age’, a number generated from a cheek swab or dried…
2 min
The Shrinking Thymus: A Hidden Predictor of How Long You’ll Live
A small organ tucked behind the breastbone, largely ignored after childhood, turns out to be one of the more powerful…
2 min
Measuring your biological age with a saliva test? Here's how reliable that actually is
More and more people are having their "biological age" determined through commercial tests: a cheek swab here, a drop of blood…
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The telomerase blueprint: we can finally see the enzyme that keeps cells young
Telomeres wear down with every cell division, and that wear counts as a biological clock.
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Sleep as a mirror of aging: a brain clock built from EEG data
The way you sleep changes measurably as you age. Researchers have used those changes to build a biological clock: an algorithm…
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The Epigenetic Clock Is Finally Growing Up, But What Does It Actually Measure?
An epigenetic clock predicts your biological age from DNA methylation patterns. Sounds precise. But what these clocks are…
2 min
The Shrinking Thymus: A Hidden Predictor of How Long You’ll Live
A small organ tucked behind the breastbone, largely ignored after childhood, turns out to be one of the more powerful…
2 min
Your internal clock determines when pain hits hardest, and the implications are huge
Scientists have discovered that the biological clock in the hypothalamus plays a direct role in how we experience pain…
1 min
Biological Age Tests Are Booming. The Science Is More Complicated Than the Marketing
Patients are arriving at clinics clutching reports of their ‘biological age’, a number generated from a cheek swab or dried…
2 min
Your immune system as a clock: how aging dismantles your defenses from the inside out
Your immune system is not just your shield against pathogens; it is also one of the first systems to buckle under the weight…
1 min
Your biological clock is ticking faster than you think - and now scientists can measure it
Imagine a clock that doesn't track the time of day, but your biological age.
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